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Reep5 receptor accessory protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364838, updated on 5-Mar-2024

Summary

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Official Symbol
Reep5provided by RGD
Official Full Name
receptor accessory protein 5provided by RGD
Primary source
RGD:1306047
See related
Ensembl:ENSRNOG00000020167 AllianceGenome:RGD:1306047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dp1
Summary
Predicted to be located in endoplasmic reticulum tubular network. Orthologous to human REEP5 (receptor accessory protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 795.8), Brain (RPKM 489.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Reep5 in Genome Data Viewer
Location:
18p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26219528..26257505, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (25945375..25983271, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27128462..27159693, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549857 Neighboring gene APC regulator of WNT signaling pathway Neighboring gene signal recognition particle 19 Neighboring gene signal recognition particle 19, pseudogene 2 Neighboring gene polycystin 2 like 2, transient receptor potential cation channel Neighboring gene Set nuclear proto-oncogene, pseudogene 8 Neighboring gene family with sequence similarity 13, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function. Yao L, et al. J Am Heart Assoc, 2018 Feb 3. PMID 29431104, Free PMC Article
  2. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. Hashimoto Y, et al. J Biol Chem, 2014 May 9. PMID 24668814, Free PMC Article
  3. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Chang J, et al. Proc Natl Acad Sci U S A, 2013 Sep 10. PMID 23969831, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REEP5 modulates cardiac function by shaping the sarcoplasmic reticulum. REEP5 defect deforms the SR architecture to depress cardiac contractility in heart failure.
    Title: REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in junctional sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 5
Names
deleted in polyposis 1
polyposis locus protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108888.2 → NP_001102358.2  receptor expression-enhancing protein 5

    See identical proteins and their annotated locations for NP_001102358.2

    Status: VALIDATED

    Source sequence(s)
    AA819308, BC167013, BE126660, BP503102, FM032375
    UniProtKB/Swiss-Prot
    B2RZ37
    UniProtKB/TrEMBL
    A0A8I6AL10
    Related
    ENSRNOP00000027345.5, ENSRNOT00000027345.6
    Conserved Domains (1) summary
    pfam03134
    Location:67 → 144
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    26219528..26257505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097000.2 → XP_038952928.1  receptor expression-enhancing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam03134
    Location:38 → 115
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RZ37.1 GenPept UniProtKB/Swiss-Prot:B2RZ37

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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