U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd19 CD19 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 365367, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Cd19provided by RGD
Official Full Name
CD19 moleculeprovided by RGD
Primary source
RGD:1309086
See related
Ensembl:ENSRNOG00000018311 AllianceGenome:RGD:1309086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 430.5) and Thymus (RPKM 64.7) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q36
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190417853..190424494, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180987286..180993920, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197815422..197822123, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 2 interacting protein Neighboring gene ribosomal protein L36 like 3 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene SH2B adaptor protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An antibody-deficiency syndrome due to mutations in the CD19 gene. van Zelm MC, et al. N Engl J Med, 2006 May 4. PMID 16672701
  2. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Rickert RC, et al. Nature, 1995 Jul 27. PMID 7543183
  3. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Carter RH, et al. Science, 1992 Apr 3. PMID 1373518
  4. Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. Buhl AM, et al. J Exp Med, 1997 Dec 1. PMID 9382888, Free PMC Article
  5. The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Mattila PK, et al. Immunity, 2013 Mar 21. PMID 23499492

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109570

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in B cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in B-1 B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
B-lymphocyte antigen CD19
Names
CD19 antigen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013237.4 → NP_001013255.2  B-lymphocyte antigen CD19 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I950
    Conserved Domains (2) summary
    cd00096
    Location:190 → 198
    Ig; Ig strand B [structural motif]
    cl11960
    Location:185 → 284
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190417853..190424494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085264.2 → XP_038941192.1  B-lymphocyte antigen CD19 isoform X1

    UniProtKB/TrEMBL
    A6I950
    Conserved Domains (2) summary
    cd00096
    Location:190 → 198
    Ig; Ig strand B [structural motif]
    cl11960
    Location:185 → 284
    Ig; Immunoglobulin domain

  2. XM_006230316.5 → XP_006230378.1  B-lymphocyte antigen CD19 isoform X2

    UniProtKB/TrEMBL
    A6I950
    Related
    ENSRNOP00000051906.3
    Conserved Domains (2) summary
    smart00410
    Location:26 → 115
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 118
    Ig; Immunoglobulin domain

  3. XM_039085277.1 → XP_038941205.1  B-lymphocyte antigen CD19 isoform X3

  4. XM_039085283.2 → XP_038941211.1  B-lymphocyte antigen CD19 isoform X3

  5. XM_063269515.1 → XP_063125585.1  B-lymphocyte antigen CD19 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous