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Slc22a12 solute carrier family 22 member 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365398, updated on 4-Jan-2025

Summary

Official Symbol
Slc22a12provided by RGD
Official Full Name
solute carrier family 22 member 12provided by RGD
Primary source
RGD:621628
See related
EnsemblRapid:ENSRNOG00000021108 AllianceGenome:RGD:621628
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rst; URAT1; Slc22al2
Summary
Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to insulin stimulus; renal urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 740.6) See more
Orthologs
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Genomic context

See Slc22a12 in Genome Data Viewer
Location:
1q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213274266..213282793, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203845039..203852496, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221910787..221919277, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097407 Neighboring gene RAS guanyl releasing protein 2 Neighboring gene neurexin 2 Neighboring gene PRELI domain containing 1, pseudogene 5 Neighboring gene ribosomal protein S6 kinase A4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC124974

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding  
enables PDZ domain binding  
enables transmembrane transporter activity  
enables urate transmembrane transporter activity  
enables urate transmembrane transporter activity  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus PubMed 
involved_in monoatomic ion transport  
involved_in organic anion transport  
involved_in renal urate salt excretion PubMed 
involved_in response to xenobiotic stimulus  
involved_in response to xenobiotic stimulus  
involved_in transmembrane transport  
involved_in urate metabolic process  
involved_in urate transport PubMed 
acts_upstream_of_or_within urate transport  
involved_in urate transport  
involved_in urate transport  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in brush border membrane  
located_in brush border membrane  
located_in membrane  
located_in membrane  
located_in membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
solute carrier family 22 member 12
Names
solute carrier family 22 (organic anion/cation transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic cation transporter)-like 2
urate anion exchanger 1
urate:anion antiporter SLC22A12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034943.1NP_001030115.1  solute carrier family 22 member 12

    See identical proteins and their annotated locations for NP_001030115.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103638
    UniProtKB/Swiss-Prot
    Q3ZAV1
    UniProtKB/TrEMBL
    A6HZI0
    Related
    ENSRNOP00000075925.1, ENSRNOT00000092270.3
    Conserved Domains (1) summary
    cd17374
    Location:109516
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213274266..213282793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269883.1XP_063125953.1  solute carrier family 22 member 12 isoform X5

  2. XM_063269880.1XP_063125950.1  solute carrier family 22 member 12 isoform X3

    UniProtKB/TrEMBL
    A6HZI0
  3. XM_063269882.1XP_063125952.1  solute carrier family 22 member 12 isoform X4

  4. XM_063269878.1XP_063125948.1  solute carrier family 22 member 12 isoform X2

  5. XM_039085569.1XP_038941497.1  solute carrier family 22 member 12 isoform X1

    UniProtKB/TrEMBL
    A6HZI0
    Conserved Domains (1) summary
    cd17374
    Location:109541
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters
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