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Lcor ligand dependent nuclear receptor corepressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 365462, updated on 13-Apr-2024

Summary

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Symbol
Lcorprovided by RGD
Full Name
ligand dependent nuclear receptor corepressorprovided by RGD
Primary source
RGD:1311704
See related
Ensembl:ENSRNOG00000042679 AllianceGenome:RGD:1311704
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311704
Summary
Predicted to enable several functions, including enzyme binding activity; estrogen receptor binding activity; and transcription corepressor binding activity. Predicted to be involved in cellular response to estradiol stimulus and positive regulation of histone H3-K27 trimethylation. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 83.5), Spleen (RPKM 65.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q54
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250247965..250354985)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240298565..240405627)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (260775091..260839549) , (260789955..260809051)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene phosphoinositide-3-kinase adaptor protein 1 Neighboring gene slit guidance ligand 1 Neighboring gene uncharacterized LOC134485238 Neighboring gene Rho GTPase activating protein 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). Kunieda T, et al. FEBS Lett, 2003 Jan 30. PMID 12560079
  2. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Wang J, et al. Nature, 2007 Apr 19. PMID 17392792
  3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ligand-dependent corepressor
Names
uncharacterized protein C10orf12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372249.1 → NP_001359178.1  ligand-dependent corepressor isoform 1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JH78
    Conserved Domains (2) summary
    pfam05225
    Location:352 → 395
    HTH_psq; helix-turn-helix, Psq domain
    pfam15782
    Location:16 → 113
    GREB1; Gene regulated by oestrogen in breast cancer

  2. NM_001401972.1 → NP_001388901.1  ligand-dependent corepressor isoform 2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000076484.1, ENSRNOT00000114892.1
    Conserved Domains (2) summary
    pfam05109
    Location:621 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1382 → 1837
    DUF4553; Domain of unknown function (DUF4553)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    250247965..250354985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085725.2 → XP_038941653.1  ligand-dependent corepressor isoform X3

    UniProtKB/TrEMBL
    A0A096MJC8, A0A8I6A097
    Related
    ENSRNOP00000068079.2
    Conserved Domains (2) summary
    pfam05109
    Location:488 → 766
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1251 → 1703
    DUF4553; Domain of unknown function (DUF4553)

  2. XM_006231418.5 → XP_006231480.1  ligand-dependent corepressor isoform X3

    See identical proteins and their annotated locations for XP_006231480.1

    UniProtKB/TrEMBL
    A0A096MJC8, A0A8I6A097
    Conserved Domains (2) summary
    pfam05109
    Location:488 → 766
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1251 → 1703
    DUF4553; Domain of unknown function (DUF4553)

  3. XM_039085693.2 → XP_038941621.1  ligand-dependent corepressor isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y016
    Conserved Domains (2) summary
    pfam05109
    Location:621 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1382 → 1837
    DUF4553; Domain of unknown function (DUF4553)

  4. XM_039085706.2 → XP_038941634.1  ligand-dependent corepressor isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y016
    Conserved Domains (2) summary
    pfam05109
    Location:621 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1382 → 1837
    DUF4553; Domain of unknown function (DUF4553)

  5. XM_039085688.2 → XP_038941616.1  ligand-dependent corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y016
    Conserved Domains (2) summary
    pfam05109
    Location:781 → 1059
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1544 → 1996
    DUF4553; Domain of unknown function (DUF4553)

  6. XM_063269996.1 → XP_063126066.1  ligand-dependent corepressor isoform X2

  7. XM_039085713.2 → XP_038941641.1  ligand-dependent corepressor isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y016
    Conserved Domains (2) summary
    pfam05109
    Location:621 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15090
    Location:1382 → 1837
    DUF4553; Domain of unknown function (DUF4553)

  8. XM_039085738.2 → XP_038941666.1  ligand-dependent corepressor isoform X4

    UniProtKB/TrEMBL
    A0A096MK42, A0A8I5Y0Y8
    Related
    ENSRNOP00000068372.2
    Conserved Domains (1) summary
    pfam05225
    Location:512 → 555
    HTH_psq; helix-turn-helix, Psq domain
Nucleotide Protein Strain
Heading Accession and Version

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