Cwf19l1 CWF19 like cell cycle control factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cwf19l1provided by RGD
Official Full Name: CWF19 like cell cycle control factor 1provided by RGD
Primary source: RGD:1304716
See related: Ensembl:ENSRNOG00000012763 AllianceGenome:RGD:1304716
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 145.0), Spleen (RPKM 122.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252946934..252970194, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242997720..243020989, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263887014..263910251, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH144568 (e-PCR)
- UniSTS:233813

AA946089 (e-PCR)
- UniSTS:250329

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA lariat debranching enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CWF19-like protein 1

Names: CWF19-like 1, cell cycle control

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108928.1 → NP_001102398.1 CWF19-like protein 1

See identical proteins and their annotated locations for NP_001102398.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHE9, D3Z863

Related

ENSRNOP00000017202.4, ENSRNOT00000017202.6

Conserved Domains (3) summary

cd07380
Location:9 → 229

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:442 → 534

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:327 → 422

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

252946934..252970194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589505.3 → XP_017444994.1 CWF19-like protein 1 isoform X1

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_017589506.3 → XP_017444995.1 CWF19-like protein 1 isoform X1

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...