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Edar ectodysplasin-A receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 365581, updated on 13-Apr-2024

Summary

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Official Symbol
Edarprovided by RGD
Official Full Name
ectodysplasin-A receptorprovided by RGD
Primary source
RGD:1561714
See related
Ensembl:ENSRNOG00000028598 AllianceGenome:RGD:1561714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561714
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of NIK/NF-kappaB signaling; and positive regulation of gene expression. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 46.1), Muscle (RPKM 12.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Edar in Genome Data Viewer
Location:
20q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27130934..27209672, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26587836..26666543, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28179132..28263092, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene coiled-coil domain containing 138 Neighboring gene uncharacterized LOC103694417 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene uncharacterized LOC134483911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Monreal AW, et al. Nat Genet, 1999 Aug. PMID 10431241
  2. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, et al. Dis Model Mech, 2019 Apr 25. PMID 31028034, Free PMC Article
  3. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Jaskoll T, et al. Anat Rec A Discov Mol Cell Evol Biol, 2003 Apr. PMID 12629675
  4. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Yan M, et al. Science, 2000 Oct 20. PMID 11039935
  5. The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndrome. Crocker M, et al. Genet Res, 1979 Dec. PMID 544312

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within salivary gland cavitation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member EDAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191899.2 → NP_001178828.1  tumor necrosis factor receptor superfamily member EDAR precursor

    See identical proteins and their annotated locations for NP_001178828.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    D3ZGP2
    Conserved Domains (2) summary
    cd13421
    Location:13 → 148
    TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
    cl14633
    Location:354 → 428
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    27130934..27209672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098902.2 → XP_038954830.1  tumor necrosis factor receptor superfamily member EDAR isoform X2

    Conserved Domains (2) summary
    cd13421
    Location:13 → 148
    TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
    cl14633
    Location:355 → 429
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_039098903.2 → XP_038954831.1  tumor necrosis factor receptor superfamily member EDAR isoform X3

    UniProtKB/TrEMBL
    D3ZGP2
    Related
    ENSRNOP00000029258.5
    Conserved Domains (2) summary
    cd13421
    Location:13 → 148
    TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
    cl14633
    Location:355 → 429
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_039098901.1 → XP_038954829.1  tumor necrosis factor receptor superfamily member EDAR isoform X1

    Conserved Domains (2) summary
    cd13421
    Location:13 → 148
    TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
    cl14633
    Location:356 → 430
    DD; Death Domain Superfamily of protein-protein interaction domains
Nucleotide Protein Strain
Heading Accession and Version

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