Mblac2 metallo-beta-lactamase domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mblac2provided by RGD
Official Full Name: metallo-beta-lactamase domain containing 2provided by RGD
Primary source: RGD:1306703
See related: Ensembl:ENSRNOG00000016252 AllianceGenome:RGD:1306703
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306703
Summary: Predicted to enable palmitoyl-CoA hydrolase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Orthologous to human MBLAC2 (metallo-beta-lactamase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 65.1), Liver (RPKM 44.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (13721752..13764558)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (11986075..12028882)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (9578501..9621297)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:493180

NoName (e-PCR)
- UniSTS:490647

RH132237 (e-PCR)
- UniSTS:215520

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-lactamase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase MBLAC2

Names: metallo-beta-lactamase domain-containing protein 2

NP_001102404.1

EC 3.1.2.2

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108934.1 → NP_001102404.1 acyl-coenzyme A thioesterase MBLAC2

See identical proteins and their annotated locations for NP_001102404.1

Status: PROVISIONAL

Source sequence(s)

CH473955

UniProtKB/TrEMBL

A6I4J1, D4A249

Related

ENSRNOP00000021756.4, ENSRNOT00000021756.7

Conserved Domains (1) summary

cd07712
Location:22 → 231

MBLAC2-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 2 and related proteins; MBL-fold metallo hydrolase domain