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Slc25a44 solute carrier family 25, member 44 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365841, updated on 5-Mar-2024

Summary

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Official Symbol
Slc25a44provided by RGD
Official Full Name
solute carrier family 25, member 44provided by RGD
Primary source
RGD:1307244
See related
Ensembl:ENSRNOG00000025269 AllianceGenome:RGD:1307244
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307244
Summary
Predicted to enable branched-chain amino acid transmembrane transporter activity. Predicted to be involved in branched-chain amino acid catabolic process; branched-chain amino acid transport; and regulation of cold-induced thermogenesis. Predicted to be located in mitochondrion. Orthologous to human SLC25A44 (solute carrier family 25 member 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 108.4), Brain (RPKM 107.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a44 in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176166136..176180965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173868317..173883137, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187772013..187786829, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene polyamine-modulated factor 1 Neighboring gene uncharacterized LOC134485637 Neighboring gene uncharacterized LOC134485636 Neighboring gene semaphorin 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Yoneshiro T, et al. Nature, 2019 Aug. PMID 31435015, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables branched-chain amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in branched-chain amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in branched-chain amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in branched-chain amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108947.1 → NP_001102417.1  solute carrier family 25 member 44

    See identical proteins and their annotated locations for NP_001102417.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    A0A0U1RRT2, A6J674, A6J675
    Related
    ENSRNOP00000075803.2, ENSRNOT00000092612.2
    Conserved Domains (2) summary
    PTZ00169
    Location:43 → 325
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:128 → 237
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176166136..176180965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102760.2 → XP_038958688.1  solute carrier family 25 member 44 isoform X3

    UniProtKB/TrEMBL
    D3ZSN7
    Conserved Domains (1) summary
    pfam00153
    Location:128 → 227
    Mito_carr; Mitochondrial carrier protein

  2. XM_039102761.2 → XP_038958689.1  solute carrier family 25 member 44 isoform X4

    UniProtKB/TrEMBL
    D3ZSN7
    Related
    ENSRNOP00000059753.2
    Conserved Domains (1) summary
    pfam00153
    Location:128 → 227
    Mito_carr; Mitochondrial carrier protein

  3. XM_039102759.2 → XP_038958687.1  solute carrier family 25 member 44 isoform X1

    UniProtKB/TrEMBL
    A6J674
    Related
    ENSRNOP00000075772.2
    Conserved Domains (1) summary
    pfam00153
    Location:120 → 229
    Mito_carr; Mitochondrial carrier protein

  4. XM_006232720.4 → XP_006232782.1  solute carrier family 25 member 44 isoform X2

    See identical proteins and their annotated locations for XP_006232782.1

    UniProtKB/TrEMBL
    A6J674
    Conserved Domains (1) summary
    pfam00153
    Location:105 → 214
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version

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