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Hipk1 homeodomain interacting protein kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365895, updated on 2-May-2024

Summary

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Official Symbol
Hipk1provided by RGD
Official Full Name
homeodomain interacting protein kinase 1provided by RGD
Primary source
RGD:1304941
See related
Ensembl:ENSRNOG00000019333 AllianceGenome:RGD:1304941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including apoptotic signaling pathway; camera-type eye morphogenesis; and protein phosphorylation. Predicted to act upstream of or within anterior/posterior pattern specification and positive regulation of cell population proliferation. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 364.5), Spleen (RPKM 316.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hipk1 in Genome Data Viewer
Location:
2q34
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193937261..193988247, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191248817..191299787, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206224015..206274910, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485758 Neighboring gene uncharacterized LOC102547265 Neighboring gene olfactomedin-like 3 Neighboring gene uncharacterized LOC108350077 Neighboring gene DNA cross-link repair 1B Neighboring gene adaptor related protein complex 4 subunit beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. Mooney SM, et al. Biochemistry, 2014 Mar 18. PMID 24559171, Free PMC Article
  2. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Kulkarni P, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289210, Free PMC Article
  3. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Kondo S, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12702766, Free PMC Article
  4. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. Li X, et al. J Biol Chem, 2005 Apr 15. PMID 15701637
  5. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. Inoue T, et al. FEBS Lett, 2010 Jul 16. PMID 20579985

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adherens junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic retina morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in iris morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in iris morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in lens induction in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in lens induction in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation IEA
Inferred from Electronic Annotation
more info
  
involved_in retina layer formation ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeodomain-interacting protein kinase 1
NP_001094456.1
XP_008759642.1
XP_038958716.1
XP_038958717.1
XP_038958720.2
XP_038958721.2
XP_038958722.2
XP_038958723.1
XP_063138349.1
XP_063138350.1
XP_063138352.1
XP_063138353.1
XP_063138354.1
XP_063138355.1
XP_063138356.1
XP_063138357.1
XP_063138358.1
XP_063138359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100986.1 → NP_001094456.1  homeodomain-interacting protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    A4L9P5, A4L9P6
    UniProtKB/TrEMBL
    F1M8I6
    Related
    ENSRNOP00000061079.3, ENSRNOT00000056079.5
    Conserved Domains (2) summary
    PHA03247
    Location:618 → 925
    PHA03247; large tegument protein UL36; Provisional
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    193937261..193988247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282287.1 → XP_063138357.1  homeodomain-interacting protein kinase 1 isoform X9

  2. XM_063282284.1 → XP_063138354.1  homeodomain-interacting protein kinase 1 isoform X6

  3. XM_063282280.1 → XP_063138350.1  homeodomain-interacting protein kinase 1 isoform X2

  4. XM_039102794.2 → XP_038958722.2  homeodomain-interacting protein kinase 1 isoform X11

  5. XM_039102792.2 → XP_038958720.2  homeodomain-interacting protein kinase 1 isoform X5

  6. XM_039102793.2 → XP_038958721.2  homeodomain-interacting protein kinase 1 isoform X10

  7. XM_063282279.1 → XP_063138349.1  homeodomain-interacting protein kinase 1 isoform X1

  8. XM_063282285.1 → XP_063138355.1  homeodomain-interacting protein kinase 1 isoform X7

  9. XM_063282286.1 → XP_063138356.1  homeodomain-interacting protein kinase 1 isoform X8

  10. XM_063282283.1 → XP_063138353.1  homeodomain-interacting protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    F1M8I6

  11. XM_063282288.1 → XP_063138358.1  homeodomain-interacting protein kinase 1 isoform X3

  12. XM_039102789.1 → XP_038958717.1  homeodomain-interacting protein kinase 1 isoform X3

    UniProtKB/Swiss-Prot
    A4L9P5, A4L9P6
    Conserved Domains (2) summary
    PHA03247
    Location:623 → 930
    PHA03247; large tegument protein UL36; Provisional
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  13. XM_008761420.4 → XP_008759642.1  homeodomain-interacting protein kinase 1 isoform X8

    UniProtKB/Swiss-Prot
    A4L9P5, A4L9P6
    Conserved Domains (2) summary
    smart00220
    Location:190 → 518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  14. XM_039102788.1 → XP_038958716.1  homeodomain-interacting protein kinase 1 isoform X3

    UniProtKB/Swiss-Prot
    A4L9P5, A4L9P6
    Conserved Domains (2) summary
    PHA03247
    Location:623 → 930
    PHA03247; large tegument protein UL36; Provisional
    cd14228
    Location:174 → 528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

  15. XM_063282282.1 → XP_063138352.1  homeodomain-interacting protein kinase 1 isoform X3

  16. XM_039102795.2 → XP_038958723.1  homeodomain-interacting protein kinase 1 isoform X13

    Conserved Domains (1) summary
    cl21453
    Location:1 → 154
    PKc_like; Protein Kinases, catalytic domain

  17. XM_063282289.1 → XP_063138359.1  homeodomain-interacting protein kinase 1 isoform X12

RNA

  1. XR_010063633.1 RNA Sequence

  2. XR_005500331.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4L9P5.1 GenPept UniProtKB/Swiss-Prot:A4L9P5

Gene LinkOut

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Research Materials
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