Bhmt2 betaine-homocysteine S-methyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bhmt2provided by RGD
Official Full Name: betaine-homocysteine S-methyltransferase 2provided by RGD
Primary source: RGD:1359418
See related: Ensembl:ENSRNOG00000040120 AllianceGenome:RGD:1359418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable S-methylmethionine-homocysteine S-methyltransferase activity; betaine-homocysteine S-methyltransferase activity; and zinc ion binding activity. Predicted to be involved in L-methionine salvage; S-adenosylmethionine metabolic process; and S-methylmethionine metabolic process. Orthologous to human BHMT2 (betaine--homocysteine S-methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2548.6) and Kidney (RPKM 1329.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (26630502..26647450, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (24895525..24912475, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (23272320..23289266, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that decreased liver Bhmt and Cbs-mediated homocysteine metabolism might have a role in hyperhomocysteinemia in polycystic ovary syndrome and provides further evidence for a potential role of decreased liver function in PCOS.
Title: Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Rat252 (e-PCR), detects polymorphism
- UniSTS:227394

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-methylmethionine-homocysteine S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-methylmethionine-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-methylmethionine-homocysteine S-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
NOT enables betaine-homocysteine S-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage	ISO Inferred from Sequence Orthology more info
involved_in S-adenosylmethionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in S-methylmethionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in S-methylmethionine metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in amino-acid betaine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-methylmethionine--homocysteine S-methyltransferase BHMT2

Names: SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2

NP_001014278.2

EC 2.1.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.