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Myo3b myosin IIIB [ Rattus norvegicus (Norway rat) ]

Gene ID: 366069, updated on 13-Apr-2024

Summary

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Symbol
Myo3bprovided by RGD
Full Name
myosin IIIBprovided by RGD
Primary source
RGD:1560313
See related
Ensembl:ENSRNOG00000030022 AllianceGenome:RGD:1560313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560313
Summary
Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Predicted to act upstream of or within positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Predicted to be located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Predicted to be part of myosin complex. Predicted to be active in stereocilium tip. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 32.8), Lung (RPKM 11.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myo3b in Genome Data Viewer
Location:
3q22
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75228017..75636272)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54820225..55228518)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56355433..56717740)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 5 Neighboring gene uncharacterized LOC134486377 Neighboring gene uncharacterized LOC134486378 Neighboring gene uncharacterized LOC134486379 Neighboring gene uncharacterized LOC120101561 Neighboring gene Sp5 transcription factor Neighboring gene glutamate-rich 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse class III myosins: kinase activity and phosphorylation sites. Dalal JS, et al. J Neurochem, 2011 Nov. PMID 21895655, Free PMC Article
  2. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Merritt RC, et al. Curr Biol, 2012 Feb 21. PMID 22264607, Free PMC Article
  3. Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments. Katti C, et al. Exp Eye Res, 2009 Aug. PMID 19332056, Free PMC Article
  4. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, et al. J Cell Biol, 2016 Jan 18. PMID 26754646, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament length IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament length ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in filopodium tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in stereocilium tip IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stereocilium tip ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium tip ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myosin-IIIb
NP_001380706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393777.1 → NP_001380706.1  myosin-IIIb

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F1LWJ6
    Related
    ENSRNOP00000032998.7, ENSRNOT00000037188.7
    Conserved Domains (3) summary
    smart00015
    Location:1102 → 1124
    IQ; Calmodulin-binding motif
    cd01379
    Location:373 → 1062
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:20 → 310
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    75228017..75636272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191901.1: Suppressed sequence

    Description
    NM_001191901.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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