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ttv tout-velu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36614, updated on 26-Apr-2024

Summary

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Official Symbol
ttvprovided by FlyBase
Official Full Name
tout-veluprovided by FlyBase
Primary source
FLYBASE:FBgn0265974
Locus tag
Dmel_CG10117
See related
AllianceGenome:FB:FBgn0265974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10117; dExt1; DEXT1; Dmel\CG10117; Ext1; EXT1; l(2)00681; l(2)05282; l(2)k00115; l(2)k03617; l(2)SH0631; l(2)SH2 0631; P1.15; Ttv
Summary
Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and acetylglucosaminyltransferase activity. Involved in several processes, including germ cell migration; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and positive regulation of signal transduction. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in organism. Human ortholog(s) of this gene implicated in chondrosarcoma; hereditary multiple exostoses; and trichorhinophalangeal syndrome type II. Orthologous to several human genes including EXT1 (exostosin glycosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51A7-51B4; 2-72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14526267..14587917)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10413772..10475422)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Additional sex combs Neighboring gene Cuticular protein 51A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lamin C Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit A Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 1 Neighboring gene transformer 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. Toyoda H, et al. J Biol Chem, 2000 Jan 28. PMID 10644674
  2. Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu. Dasgupta U, et al. Dev Genes Evol, 2007 Aug. PMID 17610078
  3. Heparan sulfate polymerization in Drosophila. Izumikawa T, et al. J Biol Chem, 2006 Jan 27. PMID 16303756
  4. Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. Kim BT, et al. J Biol Chem, 2002 Apr 19. PMID 11832488
  5. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. Toyoda H, et al. J Biol Chem, 2000 Jul 21. PMID 10806213

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hEXT1 gene was able to rescue a ttv null mutant to adulthood and restore glycosaminoglycan biosynthesis.
    Title: Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu.
  2. A novel role for toutvelu (ttv), a regulator of heparan sulfate proteoglycan biosynthesis during germ cell migration.
    Title: toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration.
  3. Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens.
    Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 14537144-14537202 mobile_element_type = transposon:INE-1{}5641

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tout-velu
Names
CG10117-PA
CG10117-PB
CG10117-PC
CG10117-PD
Tout-velu
lethal (2) SH0631
tout velour
tout velu
tout-velo
toutvelu
ttv-PA
ttv-PB
ttv-PC
ttv-PD
NP_001260971.1
NP_001260972.1
NP_001356963.1
NP_477231.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14526267..14587917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274042.1 → NP_001260971.1  tout-velu, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260971.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76796, Q5BI21, Q9V730
    UniProtKB/TrEMBL
    A0A0B4KER9
    Conserved Domains (2) summary
    pfam03016
    Location:102 → 393
    Exostosin; Exostosin family
    pfam09258
    Location:477 → 733
    Glyco_transf_64; Glycosyl transferase family 64 domain

  2. NM_001369957.1 → NP_001356963.1  tout-velu, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P7VB75
    Conserved Domains (2) summary
    pfam03016
    Location:102 → 393
    Exostosin; Exostosin family
    pfam09258
    Location:477 → 737
    Glyco_transf_64; Glycosyl transferase family 64 domain

  3. NM_057883.3 → NP_477231.1  tout-velu, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477231.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76796, Q5BI21, Q9V730
    UniProtKB/TrEMBL
    A0A0B4KER9
    Related
    FBpp0086624
    Conserved Domains (2) summary
    pfam03016
    Location:102 → 393
    Exostosin; Exostosin family
    pfam09258
    Location:477 → 733
    Glyco_transf_64; Glycosyl transferase family 64 domain

  4. NM_001274043.1 → NP_001260972.1  tout-velu, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5SHU8
    Conserved Domains (1) summary
    pfam09258
    Location:16 → 272
    Glyco_transf_64; Glycosyl transferase family 64 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KER9 A0A0B4KER9
A0A4P7VB75 A0A4P7VB75
D5SHU8 D5SHU8
Q9V730.1 Q9V730

Gene LinkOut

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