Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Tat
|
tat
|
The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription |
PubMed
|
|
tat
|
MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages |
PubMed
|
|
tat
|
Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFN regulatory factor 7A (IRF7), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection |
PubMed
|
|
tat
|
SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages |
PubMed
|
|
tat
|
HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr upregulates the expression of interferon regulatory factor 7 in human monocyte-derived macrophages |
PubMed
|
Go to the HIV-1, Human Interaction Database