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Dus4l dihydrouridine synthase 4-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 366593, updated on 13-Apr-2024

Summary

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Official Symbol
Dus4lprovided by RGD
Official Full Name
dihydrouridine synthase 4-likeprovided by RGD
Primary source
RGD:1311445
See related
Ensembl:ENSRNOG00000008155 AllianceGenome:RGD:1311445
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311445
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 13.8), Thymus (RPKM 13.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dus4l in Genome Data Viewer
Location:
6q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53955609..53970050, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48228111..48242553, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50925987..50943546, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene B-cell receptor-associated protein 29 Neighboring gene uncharacterized LOC134479362 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene large ribosomal subunit protein eL20-like Neighboring gene HMG-box transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
NP_001129275.1
XP_038968553.1
XP_038968554.1
XP_038968555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135803.2 → NP_001129275.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

    See identical proteins and their annotated locations for NP_001129275.1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K3I5, A6HB53
    Related
    ENSRNOP00000072651.2, ENSRNOT00000084533.2
    Conserved Domains (2) summary
    COG0042
    Location:32 → 311
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:28 → 257
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    53955609..53970050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112625.1 → XP_038968553.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X1

    UniProtKB/TrEMBL
    D4A0T1
    Related
    ENSRNOP00000061112.2, ENSRNOT00000068419.2
    Conserved Domains (1) summary
    cd02801
    Location:28 → 286
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. XM_039112626.1 → XP_038968554.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X2

    Conserved Domains (1) summary
    cd02801
    Location:2 → 219
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  3. XM_039112627.1 → XP_038968555.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X3

    Conserved Domains (1) summary
    cd02801
    Location:28 → 188
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
Nucleotide Protein Strain
Heading Accession and Version

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