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Ephx3 epoxide hydrolase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366836, updated on 5-Mar-2024

Summary

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Official Symbol
Ephx3provided by RGD
Official Full Name
epoxide hydrolase 3provided by RGD
Primary source
RGD:1307206
See related
Ensembl:ENSRNOG00000027319 AllianceGenome:RGD:1307206
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abhd9
Summary
Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 7.8), Heart (RPKM 4.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ephx3 in Genome Data Viewer
Location:
7q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11857367..11862674, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11206812..11212122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14212470..14217778, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 1089 Neighboring gene notch receptor 3 Neighboring gene bromodomain containing 4 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Decker M, et al. J Lipid Res, 2012 Oct. PMID 22798687, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in epoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epoxide hydrolase 3
Names
abhydrolase domain containing 9
NP_001102458.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108988.1 → NP_001102458.1  epoxide hydrolase 3

    See identical proteins and their annotated locations for NP_001102458.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/TrEMBL
    A6K941, D4A4W4
    Related
    ENSRNOP00000030761.4, ENSRNOT00000038961.5
    Conserved Domains (2) summary
    COG0596
    Location:133 → 406
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:140 → 413
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    11857367..11862674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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