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scb scab [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36692, updated on 4-Jan-2025

Summary

Official Symbol
scbprovided by FlyBase
Official Full Name
scabprovided by FlyBase
Primary source
FLYBASE:FBgn0286785
Locus tag
Dmel_CG8095
See related
AllianceGenome:FB:FBgn0286785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
&agr-PS3; alpha-PS3; alphaInt3; alphaPS3; alpha[[PS3]]; aPS3; beta[[PS3]; CG8095; CT21280; CT36929; Dm0620; Dmel\CG8095; E(Sev-CycE)E93; E(sev-cycE)[e93]; integrin; Integrin alpha PS3; ITA3; ItgaPS3; l(2)01288; l(2)51Ea; PS3; vol; Vol
Summary
Enables protein heterodimerization activity. Involved in several processes, including behavioral response to ethanol; dorsal trunk growth, open tracheal system; and heart development. Located in apical plasma membrane; basal plasma membrane; and cytoplasm. Part of integrin complex. Is expressed in several structures, including Kenyon cell; epithelium; follicle cell; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to several human genes including ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See scb in Genome Data Viewer
Location:
51E10-51E11; 2-74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15248784..15258498)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11136289..11146003)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44370 Neighboring gene uncharacterized protein Neighboring gene Hexokinase C Neighboring gene Follistatin Neighboring gene Integrin alphaPS4 subunit Neighboring gene Transient receptor potential cation channel, subfamily M Neighboring gene long non-coding RNA:CR44241

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

Interactions

General gene information

mobile_element

  • Loc: 15258246-15258290 mobile_element_type = transposon:INE-1{}5684

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables integrin binding  
enables protein heterodimerization activity PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance PubMed 
involved_in axon guidance PubMed 
involved_in behavioral response to ethanol PubMed 
involved_in cell adhesion  
involved_in cell adhesion mediated by integrin  
involved_in cell adhesion mediated by integrin  
involved_in cell migration PubMed 
involved_in cell-cell adhesion  
involved_in cell-matrix adhesion  
involved_in cell-matrix adhesion PubMed 
involved_in dorsal closure PubMed 
involved_in dorsal trunk growth, open tracheal system PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
involved_in integrin-mediated signaling pathway  
involved_in larval heart development PubMed 
involved_in memory PubMed 
involved_in midgut development PubMed 
involved_in negative regulation of cell migration PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction PubMed 
involved_in oocyte growth PubMed 
involved_in pericardium morphogenesis PubMed 
involved_in phagocytosis PubMed 
involved_in salivary gland development PubMed 
involved_in short-term memory PubMed 
involved_in wound healing PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in basal plasma membrane PubMed 
located_in cytoplasm PubMed 
is_active_in external side of plasma membrane  
located_in focal adhesion PubMed 
part_of integrin complex  
part_of integrin complex PubMed 
part_of integrin complex  
part_of integrin complex PubMed 
located_in membrane PubMed 

General protein information

Preferred Names
scab
Names
CG8095-PA
CG8095-PB
aVolado
alpha Position-Specific antigen 3
alpha3 integrin subunit
alphaPS3 integrin
alphaPS3 subunit
beta[[PS3]]integrin
complementation group 2.11
integrin
integrin alpha PS3
integrin alphaPS3 subunit
laminin receptor integrin alpha-PS3
lethal (2) 51Ea
scb-PA
scb-PB
volado

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15248784..15258498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079026.3 → NP_523750.2  scab, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523750.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44386, O44387, O46186, Q58CK3, Q6AWK3, Q9V7A3
    Related
    FBpp0086501
    Conserved Domains (3) summary
    smart00191
    Location:409 → 459
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:350 → 388
    FG-GAP; FG-GAP repeat
    pfam08441
    Location:507 → 829
    Integrin_alpha2; Integrin alpha
  2. NM_166083.2 → NP_725445.1  scab, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44386
    Related
    FBpp0086502
    Conserved Domains (3) summary
    smart00191
    Location:409 → 459
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:350 → 388
    FG-GAP; FG-GAP repeat
    pfam08441
    Location:507 → 829
    Integrin_alpha2; Integrin alpha
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