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Zfp251 zinc finger protein 251 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366954, updated on 13-Apr-2024

Summary

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Official Symbol
Zfp251provided by RGD
Official Full Name
zinc finger protein 251provided by RGD
Primary source
RGD:1311138
See related
Ensembl:ENSRNOG00000030308 AllianceGenome:RGD:1311138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf251
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in nucleus. Orthologous to human ZNF251 (zinc finger protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 101.3), Heart (RPKM 69.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp251 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110449194..110479218, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108568564..108598593, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117909976..117939274, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene uncharacterized LOC134479930 Neighboring gene U1 spliceosomal RNA Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 251

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191911.2 → NP_001178840.1  zinc finger protein 251

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    H7C5Y4
    Related
    ENSRNOP00000028184.5, ENSRNOT00000028184.7
    Conserved Domains (6) summary
    smart00349
    Location:15 → 75
    KRAB; krueppel associated box
    COG5048
    Location:82 → 467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:202 → 224
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:15 → 54
    KRAB; KRAB box
    pfam13465
    Location:356 → 381
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110449194..110479218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241854.3 → XP_006241916.1  zinc finger protein 251 isoform X1

    See identical proteins and their annotated locations for XP_006241916.1

    Conserved Domains (4) summary
    COG5048
    Location:96 → 379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:200 → 220
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:114 → 136
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:268 → 293
    zf-H2C2_2; Zinc-finger double domain

  2. XM_008765589.4 → XP_008763811.1  zinc finger protein 251 isoform X1

    See identical proteins and their annotated locations for XP_008763811.1

    Conserved Domains (4) summary
    COG5048
    Location:96 → 379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:200 → 220
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:114 → 136
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:268 → 293
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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