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Grap2 GRB2-related adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366962, updated on 5-Mar-2024

Summary

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Official Symbol
Grap2provided by RGD
Official Full Name
GRB2-related adaptor protein 2provided by RGD
Primary source
RGD:1307605
See related
Ensembl:ENSRNOG00000018316 AllianceGenome:RGD:1307605
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in several cellular components, including cytosol; endosome; and nucleoplasm. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 453.4), Spleen (RPKM 216.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Grap2 in Genome Data Viewer
Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113997356..114071073)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112117142..112190880)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121791330..121864835)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ENTH domain containing 1 Neighboring gene BAF nuclear assembly factor 1, pseudogene 5 Neighboring gene ribosomal protein L22 like 1, pseudogene 3 Neighboring gene family with sequence similarity 83, member F Neighboring gene ribosomal protein L26, pseudogene 1 Neighboring gene trinucleotide repeat containing adaptor 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Yamasaki S, et al. Int Immunol, 2008 Oct. PMID 18664516
  2. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. Tanase CA. PLoS One, 2010 Dec 15. PMID 21179510, Free PMC Article
  3. Genetic variations in humans associated with differences in the course of hepatitis C. Saito T, et al. Biochem Biophys Res Commun, 2004 Apr 30. PMID 15063762
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125066

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GRB2-related adapter protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034944.1 → NP_001030116.1  GRB2-related adapter protein 2

    See identical proteins and their annotated locations for NP_001030116.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105895
    UniProtKB/TrEMBL
    D3ZG10, Q3KR57
    Related
    ENSRNOP00000094684.1, ENSRNOT00000095205.1
    Conserved Domains (3) summary
    cd09941
    Location:54 → 147
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11950
    Location:271 → 323
    SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    cl17036
    Location:2 → 53
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    113997356..114071073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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