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Dis3l2 DIS3-like 3'-5' exoribonuclease 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367307, updated on 2-May-2024

Summary

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Official Symbol
Dis3l2provided by RGD
Official Full Name
DIS3-like 3'-5' exoribonuclease 2provided by RGD
Primary source
RGD:1560168
See related
Ensembl:ENSRNOG00000018931 AllianceGenome:RGD:1560168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560168
Summary
Predicted to enable 3'-5'-exoribonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Predicted to be involved in several processes, including RNA catabolic process; mitotic sister chromatid separation; and stem cell population maintenance. Predicted to be located in cytoplasm. Predicted to be part of exosome (RNase complex). Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 119.1), Brain (RPKM 106.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q35
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94802056..95184523)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87355409..87736616)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93767837..94161106)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480605 Neighboring gene natriuretic peptide C Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 1 Neighboring gene ribosomal protein L21, pseudogene 1 Neighboring gene alkaline phosphatase, germ cell Neighboring gene alkaline phosphatase, placental

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs. Ustianenko D, et al. RNA, 2013 Dec. PMID 24141620, Free PMC Article
  2. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Chang HM, et al. Nature, 2013 May 9. PMID 23594738, Free PMC Article
  3. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Astuti D, et al. Nat Genet, 2012 Feb 5. PMID 22306653
  4. Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Faehnle CR, et al. Nature, 2014 Oct 9. PMID 25119025, Free PMC Article
  5. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. Lubas M, et al. EMBO J, 2013 Jul 3. PMID 23756462, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid separation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in polyuridylation-dependent mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DIS3-like exonuclease 2
Names
DIS3 mitotic control homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109007.2 → NP_001102477.2  DIS3-like exonuclease 2 isoform 1

    See identical proteins and their annotated locations for NP_001102477.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CH474004
    UniProtKB/TrEMBL
    A0A0G2K6W6, A6JWJ8
    Related
    ENSRNOP00000073968.2, ENSRNOT00000084590.2
    Conserved Domains (2) summary
    COG0557
    Location:238 → 824
    VacB; Exoribonuclease R [Transcription]
    pfam17216
    Location:50 → 159
    Rrp44_CSD1; Rrp44-like cold shock domain

  2. NM_001172159.1 → NP_001165630.1  DIS3-like exonuclease 2 isoform 2

    See identical proteins and their annotated locations for NP_001165630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    CH474004
    UniProtKB/TrEMBL
    A6JWJ9, D3ZIL9
    Related
    ENSRNOP00000025779.4, ENSRNOT00000025779.6
    Conserved Domains (2) summary
    COG0557
    Location:224 → 810
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:369 → 717
    RNB; RNB domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    94802056..95184523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083980.2 → XP_038939908.1  DIS3-like exonuclease 2 isoform X3

    Conserved Domains (2) summary
    COG0557
    Location:238 → 746
    VacB; Exoribonuclease R [Transcription]
    pfam17216
    Location:50 → 159
    Rrp44_CSD1; Rrp44-like cold shock domain

  2. XM_063267518.1 → XP_063123588.1  DIS3-like exonuclease 2 isoform X4

  3. XM_039083979.2 → XP_038939907.1  DIS3-like exonuclease 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6W6, A6JWJ8
    Conserved Domains (2) summary
    COG0557
    Location:238 → 824
    VacB; Exoribonuclease R [Transcription]
    pfam17216
    Location:50 → 159
    Rrp44_CSD1; Rrp44-like cold shock domain

  4. XM_063267517.1 → XP_063123587.1  DIS3-like exonuclease 2 isoform X2

    UniProtKB/TrEMBL
    A6JWJ9, D3ZIL9

  5. XM_039083981.2 → XP_038939909.1  DIS3-like exonuclease 2 isoform X5

    UniProtKB/TrEMBL
    A6JWK0
    Conserved Domains (1) summary
    COG0557
    Location:37 → 623
    VacB; Exoribonuclease R [Transcription]
Nucleotide Protein Strain
Heading Accession and Version

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