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Atp6v1g2 ATPase H+ transporting V1 subunit G2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 368044, updated on 5-Mar-2024

Summary

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Official Symbol
Atp6v1g2provided by RGD
Official Full Name
ATPase H+ transporting V1 subunit G2provided by RGD
Primary source
RGD:1303186
See related
Ensembl:ENSRNOG00000000840 AllianceGenome:RGD:1303186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NG38; ATP6G; Atp6g2
Summary
Predicted to enable ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be integral component of synaptic vesicle membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Orthologous to human ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 681.2) and Heart (RPKM 52.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3592374..3595986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3587681..3591309, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4821265..4824829, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DExD-box helicase 39B Neighboring gene Small nucleolar RNA SNORD83 Neighboring gene small nucleolar RNA SNORD83 Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene tumor necrosis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Does the rat have an H2-D orthologue next to Bat1? Lambracht-Washington D, et al. Immunogenetics, 2002 Mar. PMID 11904681
  2. Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons. Murata Y, et al. J Biol Chem, 2002 Sep 27. PMID 12133826
  3. Structure of V-ATPase from the mammalian brain. Abbas YM, et al. Science, 2020 Mar 13. PMID 32165585, Free PMC Article
  4. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity TAS
Traceable Author Statement
more info
 PubMed 
enables P-type proton-exporting transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle lumen acidification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase complex TAS
Traceable Author Statement
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit G 2
Names
ATPase, H+ transporting, V1 subunit G
ATPase, H+ transporting, lysosomal V1 subunit G2
lysosomal ATPase
vacuolar ATPase NG38
NP_997655.1
XP_008770957.1
XP_038954849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212490.2 → NP_997655.1  V-type proton ATPase subunit G 2

    See identical proteins and their annotated locations for NP_997655.1

    Status: VALIDATED

    Source sequence(s)
    BX883046
    UniProtKB/TrEMBL
    F7EMR7, Q8R2H0
    Related
    ENSRNOP00000001114.2, ENSRNOT00000001114.6
    Conserved Domains (1) summary
    pfam03179
    Location:3 → 107
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3592374..3595986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772735.4 → XP_008770957.1  V-type proton ATPase subunit G 2 isoform X1

    See identical proteins and their annotated locations for XP_008770957.1

    UniProtKB/TrEMBL
    A0A0G2KAG3
    Conserved Domains (1) summary
    cl03922
    Location:1 → 66
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit

  2. XM_039098921.2 → XP_038954849.1  V-type proton ATPase subunit G 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAG3
    Conserved Domains (1) summary
    cl03922
    Location:1 → 66
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit
Nucleotide Protein Strain
Heading Accession and Version

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