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skap2 src kinase associated phosphoprotein 2 [ Danio rerio (zebrafish) ]

Gene ID: 368564, updated on 27-Mar-2024

Summary

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Official Symbol
skap2provided by ZNC
Official Full Name
src kinase associated phosphoprotein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-438
See related
Ensembl:ENSDARG00000000906 AllianceGenome:ZFIN:ZDB-GENE-030616-438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
scap2; SKAP55; zgc:65975; zgc:158223; si:dz31b14.4; si:dz227h09.6
Summary
Predicted to enable kinase activity. Predicted to act upstream of or within B cell activation and phosphorylation. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (20934358..20977712)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (21128539..21171890)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886298 Neighboring gene homeobox A9b Neighboring gene homeobox A2b Neighboring gene sorting nexin 10b Neighboring gene chromobox homolog 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC65975

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
src kinase-associated phosphoprotein 2
Names
SKAP55 homolog
src family-associated phosphoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200628.1 → NP_956922.1  src kinase-associated phosphoprotein 2

    See identical proteins and their annotated locations for NP_956922.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057253
    UniProtKB/Swiss-Prot
    Q6PG29
    Related
    ENSDARP00000052659.5, ENSDART00000052660.7
    Conserved Domains (3) summary
    cd12045
    Location:283 → 335
    SH3_SKAP2; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
    cd13381
    Location:106 → 211
    PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:106 → 208
    PH; PH domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    20934358..20977712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157963.4 → XP_005158020.1  src kinase-associated phosphoprotein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4Y0
    Conserved Domains (3) summary
    cd12045
    Location:282 → 334
    SH3_SKAP2; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
    cd13381
    Location:106 → 211
    PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:106 → 208
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PG29.1 GenPept UniProtKB/Swiss-Prot:Q6PG29

Gene LinkOut

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