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aifm1 apoptosis inducing factor mitochondrion associated 1 [ Danio rerio (zebrafish) ]

Gene ID: 373125, updated on 25-Apr-2024

Summary

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Official Symbol
aifm1provided by ZNC
Official Full Name
apoptosis inducing factor mitochondrion associated 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-11
See related
Ensembl:ENSDARG00000058088 AllianceGenome:ZFIN:ZDB-GENE-030826-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
AIF; pdcd8; zgc:91994
Summary
Predicted to enable FAD binding activity and NAD(P)H oxidase H2O2-forming activity. Predicted to be involved in apoptotic process and mitochondrial respiratory chain complex assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and polster. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22550614..22573724, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22046814..22069932, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A Neighboring gene glycine receptor, alpha 4b Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 like 4 Neighboring gene caspase 22, apoptosis-related cysteine peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish. Zhou T, et al. Int J Nanomedicine, 2016. PMID 27980407, Free PMC Article
  2. Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill. Luzio A, et al. Aquat Toxicol, 2013 Mar 15. PMID 23314331
  3. Apoptosis-related genes induced in response to ketamine during early life stages of zebrafish. Félix LM, et al. Toxicol Lett, 2017 Sep 5. PMID 28716577
  4. MS-222 induces biochemical and transcriptional changes related to oxidative stress, cell proliferation and apoptosis in zebrafish embryos. Félix LM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2020 Nov. PMID 32585370
  5. Malformations and mortality in zebrafish early stages associated with elevated caspase activity after 24 h exposure to MS-222. Félix LM, et al. Toxicol Appl Pharmacol, 2021 Feb 1. PMID 33370555

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)H oxidase H2O2-forming activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apoptosis-inducing factor 1, mitochondrial
Names
programmed cell death 8 (apoptosis-inducing factor)
NP_956396.2
XP_005165182.1
XP_005165184.1
XP_009299566.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200102.2 → NP_956396.2  apoptosis-inducing factor 1, mitochondrial

    See identical proteins and their annotated locations for NP_956396.2

    Status: PROVISIONAL

    Source sequence(s)
    BC084689
    UniProtKB/TrEMBL
    Q5XFY2
    Related
    ENSDARP00000075326.4, ENSDART00000080882.6
    Conserved Domains (3) summary
    pfam00070
    Location:304 → 388
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:139 → 449
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:467 → 593
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    22550614..22573724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165127.3 → XP_005165184.1  apoptosis-inducing factor 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M2BCF4
    Conserved Domains (3) summary
    pfam00070
    Location:431 → 515
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:266 → 576
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:594 → 720
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

  2. XM_009301291.2 → XP_009299566.1  apoptosis-inducing factor 1, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8M3AS24
    Conserved Domains (3) summary
    pfam00070
    Location:312 → 396
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:147 → 457
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:475 → 601
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

  3. XM_005165125.3 → XP_005165182.1  apoptosis-inducing factor 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCB6
    Related
    ENSDARP00000120028.1, ENSDART00000131889.3
    Conserved Domains (4) summary
    pfam00070
    Location:439 → 523
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:274 → 584
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:602 → 728
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
    pfam14962
    Location:56 → 203
    AIF-MLS; Mitochondria Localization Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394573.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    65676..88735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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