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GlyT Glycine transporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37772, updated on 4-Jan-2025

Summary

Official Symbol
GlyTprovided by FlyBase
Official Full Name
Glycine transporterprovided by FlyBase
Primary source
FLYBASE:FBgn0034911
Locus tag
Dmel_CG5549
See related
AllianceGenome:FB:FBgn0034911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5549; dGlyT; Dmel\CG5549
Summary
Enables glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Involved in glycine import across plasma membrane; neurotransmitter transport; and regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Orthologous to several human genes including SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See GlyT in Genome Data Viewer
Location:
60A2-60A3; 2-105 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23820354..23839864)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19707877..19727387)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44807 Neighboring gene uncharacterized protein Neighboring gene NTF2-related export protein 1 Neighboring gene pippin Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR44805

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in amino acid transport  
involved_in glycine import across plasma membrane PubMed 
involved_in glycine transport PubMed 
involved_in neurotransmitter transport PubMed 
involved_in neurotransmitter transport PubMed 
involved_in regulation of circadian rhythm PubMed 
involved_in sodium ion transmembrane transport  
Component Evidence Code Pubs
located_in membrane  
located_in membrane PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
glycine transporter
Names
CG5549-PB
GlyT-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23820354..23839864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137992.3NP_611836.2  glycine transporter [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611836.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1J0
    Conserved Domains (1) summary
    pfam00209
    Location:57603
    SNF; Sodium:neurotransmitter symporter family
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