egfra epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: egfraprovided by ZNC
Official Full Name: epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030918-1
See related: Ensembl:ENSDARG00000013847 AllianceGenome:ZFIN:ZDB-GENE-030918-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: egfr; EGFR12; EGFR15
Summary: Predicted to enable epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gill; liver; nervous system; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (3696038..3820159)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (3864859..3989270)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes beta-catenin signaling during hematopoietic stem cell development in zebrafish.
Title: EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish.
Epidermal growth factor receptor promotes high-fructose nonalcoholic fatty liver disease by inducing mitochondrial fission in zebrafish.
Title: Epidermal growth factor receptor promotes high-fructose nonalcoholic fatty liver disease by inducing mitochondrial fission in zebrafish.
Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
Title: Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance.
Title: Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
Title: Insulin-like growth factor I promotes oocyte maturation through increasing the expression and phosphorylation of epidermal growth factor receptor in the zebrafish ovary.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
Title: Role of Pgrmc1 in estrogen maintenance of meiotic arrest in zebrafish oocytes through Gper/Egfr.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
Title: Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G protein-coupled estrogen receptor (Gper) in zebrafish (Danio rerio).
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Title: Cloning of epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells.

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General gene information

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Markers

fb09c06.x1 (e-PCR)
- UniSTS:189980

fa97e01.x1 (e-PCR)
- UniSTS:189744

fc02h08.x1 (e-PCR)
- UniSTS:192089

fc23d08.x1 (e-PCR)
- UniSTS:193148

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel lumenization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel lumenization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell communication	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: epidermal growth factor receptor

Names: erbb1a

NP_919405.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194424.1 → NP_919405.1 epidermal growth factor receptor precursor

See identical proteins and their annotated locations for NP_919405.1

Status: PROVISIONAL

Source sequence(s)

AY154658

UniProtKB/TrEMBL

Q7SZF7

Related

ENSDARP00000132819.1, ENSDART00000164152.3

Conserved Domains (7) summary

smart00261
Location:550 → 596

FU; Furin-like repeats

cd00064
Location:229 → 274

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05108
Location:703 → 1014

PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor

pfam00757
Location:184 → 333

Furin-like; Furin-like cysteine rich region

pfam01030
Location:359 → 479

Recep_L_domain; Receptor L domain

pfam07714
Location:711 → 967

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:503 → 634

GF_recep_IV; Growth factor receptor domain IV