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drd2.L dopamine receptor D2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378584, updated on 4-Jan-2025

Summary

Official Symbol
drd2.L
Official Full Name
dopamine receptor D2 L homeolog
Primary source
Xenbase:XB-GENE-1005782
Locus tag
XELAEV_18035548mg
See related
EnsemblRapid:ENSXLAG00005012137 AllianceGenome:Xenbase:XB-GENE-1005782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
d2r; d2dr; drd2; drd2-a; drd2-b
Summary
Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity. Predicted to act upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway and regulation of secretion by cell. Predicted to be located in Golgi membrane and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See drd2.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (88216176..88389391)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (79599762..79773525)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene transmembrane protease serine 5 Neighboring gene uncharacterized LOC121395763 Neighboring gene syncytin-2-like Neighboring gene ankyrin repeat and kinase domain containing 1 L homeolog Neighboring gene tetratricopeptide repeat domain 12 L homeolog

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi membrane  
located_in membrane  
located_in plasma membrane  

General protein information

Preferred Names
D(2) dopamine receptor A
Names
D2R 1
D2R-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101742.1NP_001095212.1  D(2) dopamine receptor A

    See identical proteins and their annotated locations for NP_001095212.1

    Status: PROVISIONAL

    Source sequence(s)
    X59500
    UniProtKB/Swiss-Prot
    P24628
    Related
    ENSXLAP00005035532.1, ENSXLAT00005036425.1
    Conserved Domains (2) summary
    pfam00001
    Location:45425
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40219
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    88216176..88389391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568349.1XP_041424283.1  D(2) dopamine receptor A isoform X1

    UniProtKB/TrEMBL
    A0A1L8FLX5, A0A974CG51
    Conserved Domains (1) summary
    cd15309
    Location:29432
    7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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