Qrfp pyroglutamylated RFamide peptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Qrfpprovided by RGD
Official Full Name: pyroglutamylated RFamide peptideprovided by RGD
Primary source: RGD:735020
See related: Ensembl:ENSRNOG00000046473 AllianceGenome:RGD:735020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P518; 26RFa; NEWGENE_735020
Summary: Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including grooming behavior; neuropeptide signaling pathway; and regulation of feeding behavior. Predicted to be located in extracellular region. Orthologous to human QRFP (pyroglutamylated RFamide peptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35485579..35487902, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15088045..15088419, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9402397..9404354)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies support a role for estradiol (E2) in the regulation of prepro-QRFP mRNA in the ventral medial nucleus of the hypothalamus/arcuate nucleus and suggest that E2's effects on food intake may be via a direct effect on the orexigenic peptide, QRFP.
Title: The effects of high fat diet and estradiol on hypothalamic prepro-QRFP mRNA expression in female rats.
The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat.
Title: Hypothalamic QRFP: regulation of food intake and fat selection.
QRFP 43 might play a role downstream of leptin in the regulation of feeding behavior.
Title: Suppression of QRFP 43 in the hypothalamic ventromedial nucleus of Long-Evans rats fed a high-fat diet.
QRFP may play a role in coordinating feeding behaviors with reproductive function in rats when energy demand is increased.
Title: QRFP in female rats: effects on high fat food intake and hypothalamic gene expression across the estrous cycle.
Data suggest that the GPR103-26RFa system modulates nociceptive transmission in both the spinal cord and the supraspinal brain in the formalin (paw) test.
Title: Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.
QRFP mRNA was highly expressed in the hypothalamus; QRFP receptor mRNA was highly expressed in the adrenal gland. Data suggests that QRFP and its receptor have a regulatory function in the rat adrenal gland.
Title: A new peptidic ligand and its receptor regulating adrenal function in rats.
Prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior.
Title: Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals.
potential role of the orexigenic peptide 26RFa in the control of the gonadotropic axis, thus suggesting its potential involvement in the joint control of energy balance and reproduction, especially in the female
Title: Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables orexigenic neuropeptide QRFP receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables orexigenic neuropeptide QRFP receptor binding	ISO Inferred from Sequence Orthology more info
enables orexigenic neuropeptide QRFP receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in grooming behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: orexigenic neuropeptide QRFP

Names: P518 precursor protein; neuropeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.