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pon2.L paraoxonase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380341, updated on 4-Jan-2025

Summary

Official Symbol
pon2.L
Official Full Name
paraoxonase 2 L homeolog
Primary source
Xenbase:XB-GENE-491658
Locus tag
XELAEV_18030881mg
See related
EnsemblRapid:ENSXLAG00005029161 AllianceGenome:Xenbase:XB-GENE-491658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
esa; pon; pon1; pon2; mvcd5
Summary
Predicted to enable arylesterase activity and metal ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See pon2.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (33102978..33122732, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (30627753..30647519, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 9A L homeolog Neighboring gene serum paraoxonase/arylesterase 2-like Neighboring gene pyruvate dehydrogenase kinase 4 L homeolog Neighboring gene dynein cytoplasmic 1 intermediate chain 1 L homeolog

Genomic regions, transcripts, and products

General gene information

Clone Names

  • MGC53915

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables arylesterase activity  
enables hydrolase activity  
enables metal ion binding  

General protein information

Preferred Names
serum paraoxonase/arylesterase 2
Names
paraoxonase 1
NP_001080649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087180.1NP_001080649.1  serum paraoxonase/arylesterase 2

    See identical proteins and their annotated locations for NP_001080649.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044294
    UniProtKB/TrEMBL
    A0A974CM29, Q7ZTN3
    Related
    ENSXLAP00005087109.1, ENSXLAT00005088771.1
    Conserved Domains (2) summary
    cl16912
    Location:57137
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    cl22863
    Location:169254
    Str_synth; Strictosidine synthase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    33102978..33122732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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