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Glut1 Glucose transporter 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38109, updated on 4-Jan-2025

Summary

Official Symbol
Glut1provided by FlyBase
Official Full Name
Glucose transporter 1provided by FlyBase
Primary source
FLYBASE:FBgn0264574
Locus tag
Dmel_CG43946
See related
AllianceGenome:FB:FBgn0264574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0074/12; CG1086; CG13908; CG43946; Dmel\CG43946; Dmglut1; DmGluT1; DmGLUT1; Glt1; GLU; Glu T1; Glut; GLUT; Glut-1; glut1; GLUT1; l(3)61Ea; l(3)L1H; l(3)S007412
Old locus tag
Dmel_CG1086; Dmel_CG13908
Summary
Predicted to enable hexose transmembrane transporter activity. Involved in glucose homeostasis and positive regulation of peptide hormone secretion. Predicted to be active in membrane. Is expressed in adult head; embryonic antennal sense organ; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose metabolism disease (multiple); glycogen storage disease; myelomeningocele; and obesity. Orthologous to several human genes including SLC2A14 (solute carrier family 2 member 14) and SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Glut1 in Genome Data Viewer
Location:
61D4-61E1; 3-0.5 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (914074..993788)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (914074..993788)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene nervous fingers 1 Neighboring gene materazzi Neighboring gene long non-coding RNA:CR45809 Neighboring gene long non-coding RNA:CR45810 Neighboring gene long non-coding RNA:CR45811 Neighboring gene allnighter Neighboring gene trio

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

mobile_element

  • Loc: 925231-932599 mobile_element_type = transposon:mdg1{}900

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in membrane  
located_in membrane  

General protein information

Preferred Names
glucose transporter 1
Names
CG43946-PAA
CG43946-PB
CG43946-PC
CG43946-PD
CG43946-PE
CG43946-PJ
CG43946-PL
CG43946-PM
CG43946-PO
CG43946-PP
CG43946-PQ
CG43946-PR
CG43946-PS
CG43946-PT
CG43946-PU
CG43946-PV
CG43946-PW
CG43946-PX
CG43946-PY
CG43946-PZ
Glut1-PAA
Glut1-PB
Glut1-PC
Glut1-PD
Glut1-PE
Glut1-PJ
Glut1-PL
Glut1-PM
Glut1-PO
Glut1-PP
Glut1-PQ
Glut1-PR
Glut1-PS
Glut1-PT
Glut1-PU
Glut1-PV
Glut1-PW
Glut1-PX
Glut1-PY
Glut1-PZ
glucose transporter
lethal (3) S007412

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    914074..993788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274304.1 → NP_001261233.1  glucose transporter 1, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261233.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:304 → 746
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:305 → 764
    Sugar_tr; Sugar (and other) transporter
    cl00143
    Location:176 → 256
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  2. NM_001274303.1 → NP_001261232.1  glucose transporter 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261232.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:121 → 515
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:74 → 533
    Sugar_tr; Sugar (and other) transporter
    pfam05384
    Location:15 → 52
    DegS; Sensor protein DegS
  3. NM_001274305.1 → NP_001261234.1  glucose transporter 1, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
  4. NM_167846.3 → NP_728558.5  glucose transporter 1, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728558.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:253 → 606
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:289 → 598
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
    pfam05384
    Location:181 → 242
    DegS; Sensor protein DegS
  5. NM_001274306.1 → NP_001261235.1  glucose transporter 1, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261235.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (1) summary
    pfam07851
    Location:159 → 251
    TMPIT; TMPIT-like protein
  6. NM_001316474.1 → NP_001303403.1  glucose transporter 1, isoform AA [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WFC8
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  7. NM_001299966.1 → NP_001286895.1  glucose transporter 1, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JG36
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  8. NM_001299967.1 → NP_001286896.1  glucose transporter 1, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JBV9
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  9. NM_138229.2 → NP_612073.2  glucose transporter 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612073.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8JNH6, A8JNH8, A8JNH9, M9PBH4, M9PBH5, M9PDK7, M9PDL1, M9PDS4, M9PDS9, M9PE46, M9PGN5, M9PGP2, O77131, Q0E8K0, Q6NNA9, Q8IRI6, Q95TE8, Q9V409, Q9W0L2
    Conserved Domains (2) summary
    cd06174
    Location:17 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  10. NM_001274309.1 → NP_001261238.1  glucose transporter 1, isoform X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261238.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (4) summary
    cd06174
    Location:253 → 688
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR04211
    Location:117 → 236
    SH3_and_anchor; SH3 domain protein
    pfam00083
    Location:254 → 706
    Sugar_tr; Sugar (and other) transporter
    pfam05384
    Location:181 → 242
    DegS; Sensor protein DegS
  11. NM_001274301.1 → NP_001261230.1  glucose transporter 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261230.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  12. NM_001274302.1 → NP_001261231.1  glucose transporter 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JBV9
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  13. NM_001104000.2 → NP_001097470.2  glucose transporter 1, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097470.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (2) summary
    cd06174
    Location:17 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  14. NM_001274308.1 → NP_001261237.1  glucose transporter 1, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:253 → 688
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:254 → 706
    Sugar_tr; Sugar (and other) transporter
    pfam05384
    Location:181 → 242
    DegS; Sensor protein DegS
  15. NM_001103999.4 → NP_001097469.2  glucose transporter 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097469.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:152 → 546
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:105 → 564
    Sugar_tr; Sugar (and other) transporter
    pfam05384
    Location:32 → 93
    DegS; Sensor protein DegS
  16. NM_001103997.3 → NP_001097467.1  glucose transporter 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097467.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  17. NM_001274307.1 → NP_001261236.1  glucose transporter 1, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261236.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (3) summary
    cd06174
    Location:253 → 688
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:254 → 706
    Sugar_tr; Sugar (and other) transporter
    pfam05384
    Location:181 → 242
    DegS; Sensor protein DegS
  18. NM_001103998.3 → NP_001097468.1  glucose transporter 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Conserved Domains (2) summary
    cd06174
    Location:65 → 459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 477
    Sugar_tr; Sugar (and other) transporter
  19. NM_079154.3 → NP_523878.1  glucose transporter 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523878.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Related
    FBpp0305681
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
  20. NM_167845.3 → NP_728557.1  glucose transporter 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRI6
    Related
    FBpp0305680
    Conserved Domains (2) summary
    cd06174
    Location:65 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:18 → 470
    Sugar_tr; Sugar (and other) transporter
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