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Marchf4 membrane associated ring-CH-type finger 4 [ Mus musculus (house mouse) ]

Gene ID: 381270, updated on 5-Mar-2024

Summary

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Official Symbol
Marchf4provided by MGI
Official Full Name
membrane associated ring-CH-type finger 4provided by MGI
Primary source
MGI:MGI:2683550
See related
Ensembl:ENSMUSG00000039372 AllianceGenome:MGI:2683550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
March4; MARCH-IV; mKIAA1399
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be located in Golgi stack and trans-Golgi network. Orthologous to human MARCHF4 (membrane associated ring-CH-type finger 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 3.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C3; 1 36.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72466271..72576454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72427112..72537159, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4322 Neighboring gene STARR-seq mESC enhancer starr_01273 Neighboring gene STARR-seq mESC enhancer starr_01274 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 Neighboring gene STARR-seq mESC enhancer starr_01276 Neighboring gene predicted gene, 39661 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01277 Neighboring gene SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1548 Neighboring gene STARR-seq mESC enhancer starr_01281 Neighboring gene predicted gene, 39662 Neighboring gene STARR-seq mESC enhancer starr_01283 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene ribosomal protein L19 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. Li Q, et al. PLoS Genet, 2014 Jul. PMID 25079229, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA1399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF4
Names
E3 ubiquitin-protein ligase MARCH4
RING-type E3 ubiquitin transferase MARCH4
RING-type E3 ubiquitin transferase MARCHF4
membrane-associated RING finger protein 4
membrane-associated RING-CH protein IV
membrane-associated ring finger (C3HC4) 4
NP_001038998.1
NP_001408016.1
XP_036021943.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045533.2 → NP_001038998.1  E3 ubiquitin-protein ligase MARCHF4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001038998.1

    Status: VALIDATED

    Source sequence(s)
    AC114629, AC163484
    Consensus CDS
    CCDS15034.1
    UniProtKB/Swiss-Prot
    Q4QQN4, Q80TE3
    Related
    ENSMUSP00000042803.6, ENSMUST00000047786.6
    Conserved Domains (1) summary
    cd16811
    Location:161 → 211
    RING_CH-C4HC3_MARCH4_9; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH4, MARCH9, and similar proteins

  2. NM_001421087.1 → NP_001408016.1  E3 ubiquitin-protein ligase MARCHF4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC114629, AC163484

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72466271..72576454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166050.1 → XP_036021943.1  E3 ubiquitin-protein ligase MARCHF4 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:162 → 207
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:161 → 211
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_004942942.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TE3.3 GenPept UniProtKB/Swiss-Prot:Q80TE3

Gene LinkOut

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