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Cht2 Chitinase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38223, updated on 10-May-2024

Summary

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Official Symbol
Cht2provided by FlyBase
Official Full Name
Chitinase 2provided by FlyBase
Primary source
FLYBASE:FBgn0022702
Locus tag
Dmel_CG2054
See related
AllianceGenome:FB:FBgn0022702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2054; Cht; Cht-2; cht2; CHT2; DmCht2; DmCHT2; Dmel\CG2054
Summary
Predicted to enable chitin binding activity and chitinase activity. Involved in chitin-based cuticle development; ecdysis, chitin-based cuticle; and wound healing. Located in extracellular space. Is expressed in several structures, including embryonic/larval tracheal system; epidermis; gut section; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
62B1-62B1; 3-1.0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1752328..1755934, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1752328..1755934, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W b Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 62B Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Chitinase 2 is expressed in chitin producing organs for cuticle formation. Pesch YY, et al. Arthropod Struct Dev, 2017 Jan. PMID 27832982
  2. Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila. de la Vega H, et al. Insect Mol Biol, 1998 Aug. PMID 9662472
  3. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
  4. Obstructor-A is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis. Petkau G, et al. J Biol Chem, 2012 Jun 15. PMID 22544743, Free PMC Article
  5. Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response. Everman ER, et al. Evolution, 2018 Feb. PMID 29214647

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chitinase 2
Names
CG2054-PA
CG2054-PB
CG2054-PC
Cht2-PA
Cht2-PB
Cht2-PC
NP_001246550.1
NP_001261282.1
NP_477298.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1752328..1755934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259621.2 → NP_001246550.1  chitinase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246550.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17421, Q9W092
    UniProtKB/TrEMBL
    D0IQG7
    Conserved Domains (2) summary
    cd02872
    Location:43 → 428
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:42 → 389
    Glyco_18; Glyco_18 domain

  2. NM_001274353.1 → NP_001261282.1  chitinase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261282.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17421, Q9W092
    UniProtKB/TrEMBL
    D0IQG7
    Conserved Domains (2) summary
    cd02872
    Location:43 → 428
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:42 → 389
    Glyco_18; Glyco_18 domain

  3. NM_057950.4 → NP_477298.2  chitinase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477298.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17421, Q9W092
    UniProtKB/TrEMBL
    D0IQG7
    Related
    FBpp0072677
    Conserved Domains (2) summary
    cd02872
    Location:43 → 428
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:42 → 389
    Glyco_18; Glyco_18 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0IQG7 D0IQG7
Q9W092.1 Q9W092

Gene LinkOut

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