oxt peptide O-xylosyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: oxtprovided by FlyBase
Official Full Name: peptide O-xylosyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0015360
Locus tag: Dmel_CG32300
See related: AllianceGenome:FB:FBgn0015360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-i2; CG17771; CG17772; CG32300; Dmel\CG32300; dOXT; dXylT; Oxt; OXT
Summary: Enables protein xylosyltransferase activity. Involved in D-xylose metabolic process and proteoglycan metabolic process. Predicted to be located in membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Orthologous to human XYLT1 (xylosyltransferase 1) and XYLT2 (xylosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2258839..2262664, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2258839..2262664, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase
Title: Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteoglycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein xylosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein xylosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-xylose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chondroitin sulfate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

Names: CG32300-PB; O-xylosyltransferase; Peptide-O-xylosyl-transferase; Peptide-o-xylosyltransferase; drosophila peptide O-xylosyltransferase; oxt-PB

NP_647705.1

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The following sections contain reference sequences that belong to a specific genome build. Explain