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KIF11 kinesin family member 11 [ Homo sapiens (human) ]

Gene ID: 3832, updated on 4-Jan-2025

Summary

Official Symbol
KIF11provided by HGNC
Official Full Name
kinesin family member 11provided by HGNC
Primary source
HGNC:HGNC:6388
See related
Ensembl:ENSG00000138160 MIM:148760; AllianceGenome:HGNC:6388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EG5; HKSP; KNSL1; MCLMR; TRIP5
Summary
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 9.9), bone marrow (RPKM 8.6) and 18 other tissues See more
Orthologs
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Genomic context

See KIF11 in Genome Data Viewer
Location:
10q23.33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92593130..92655395)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93472467..93534736)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94352887..94415152)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902484 Neighboring gene insulin degrading enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3774 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94352873-94353624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94357207-94357722 Neighboring gene ribosomal protein L11 pseudogene 4 Neighboring gene uncharacterized LOC124902594 Neighboring gene RNA, 7SL, cytoplasmic 644, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2013-08-01)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2013-08-01)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates EG5 activity allosterically by blocking ADP release from EG5. Residue K85 in EG5 is important for Tat-mediated suppression of EG5 activity and Tat-induced apoptosis during mitotic arrest PubMed
tat Pull-down/immunoprecipitation assays demonstrate that HIV-1 Tat interacts with EG5 in cells. The carboxyl-terminal domain (residues 73-101) of Tat and the amino-terminal half (residues 1-517) of EG5 are involved in the interaction between Tat and EG5 PubMed
Vif vif HIV Vif interacts with KIF11 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables microtubule binding  
enables microtubule motor activity PubMed 
enables plus-end-directed microtubule motor activity  
enables protein binding PubMed 
enables protein kinase binding PubMed 
Process Evidence Code Pubs
involved_in cell division  
involved_in microtubule-based movement  
involved_in mitotic cell cycle PubMed 
involved_in mitotic centrosome separation  
involved_in mitotic spindle assembly  
involved_in mitotic spindle assembly PubMed 
involved_in mitotic spindle assembly PubMed 
involved_in mitotic spindle organization PubMed 
involved_in regulation of mitotic centrosome separation PubMed 
involved_in spindle elongation  
involved_in spindle organization PubMed 
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
part_of kinesin complex PubMed 
located_in membrane PubMed 
located_in microtubule PubMed 
is_active_in mitotic spindle  
located_in mitotic spindle  
is_active_in nucleus  
part_of protein-containing complex PubMed 
located_in spindle PubMed 
colocalizes_with spindle microtubule PubMed 
colocalizes_with spindle pole PubMed 

General protein information

Preferred Names
kinesin-like protein KIF11
Names
TR-interacting protein 5
TRIP-5
kinesin-like protein 1
kinesin-like spindle protein HKSP
kinesin-related motor protein Eg5
thyroid receptor-interacting protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032580.1 RefSeqGene

    Range
    5063..67328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004523.4NP_004514.2  kinesin-like protein KIF11

    See identical proteins and their annotated locations for NP_004514.2

    Status: REVIEWED

    Source sequence(s)
    AA504625, BC136474, BM742618, CU446438, DB078134
    Consensus CDS
    CCDS7422.1
    UniProtKB/Swiss-Prot
    A0AV49, B2RMV3, P52732, Q15716, Q5VWX0
    UniProtKB/TrEMBL
    B2RAM6
    Related
    ENSP00000260731.3, ENST00000260731.5
    Conserved Domains (3) summary
    smart00129
    Location:18366
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01364
    Location:16368
    KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
    pfam13931
    Location:9161053
    Microtub_bind; Kinesin-associated microtubule-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    92593130..92655395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    93472467..93534736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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