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Irs2 insulin receptor substrate 2 [ Mus musculus (house mouse) ]

Gene ID: 384783, updated on 13-Jan-2025

Summary

Official Symbol
Irs2provided by MGI
Official Full Name
insulin receptor substrate 2provided by MGI
Primary source
MGI:MGI:109334
See related
Ensembl:ENSMUSG00000038894 AllianceGenome:MGI:109334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irs-2
Summary
Enables phosphatidylinositol 3-kinase activator activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of B cell proliferation; and positive regulation of cell communication. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of cell population proliferation; and positive regulation of epithelial cell migration. Located in cytosol and plasma membrane. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in small intestine adult (RPKM 23.9), mammary gland adult (RPKM 19.4) and 28 other tissues See more
Orthologs
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Genomic context

See Irs2 in Genome Data Viewer
Location:
8 A1.1; 8 5.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11034681..11058929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10984681..11008929, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3930402G23 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:10945940-10946240 Neighboring gene predicted gene, 32594 Neighboring gene RIKEN cDNA 9530052E02 gene Neighboring gene STARR-positive B cell enhancer ABC_E3768 Neighboring gene predicted gene 44717 Neighboring gene predicted gene 15418 Neighboring gene collagen, type IV, alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding  
enables 14-3-3 protein binding  
enables insulin receptor binding  
enables insulin receptor binding  
enables insulin receptor binding  
enables phosphatidylinositol 3-kinase activator activity PubMed 
enables phosphatidylinositol 3-kinase binding  
enables phosphatidylinositol 3-kinase binding PubMed 
enables phosphatidylinositol 3-kinase binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding  
enables protein kinase binding PubMed 
enables protein phosphatase binding  
enables protein phosphatase binding  
enables protein-macromolecule adaptor activity PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
acts_upstream_of_or_within brain development PubMed 
acts_upstream_of cell migration PubMed 
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cellular response to glucose stimulus  
acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
involved_in cellular response to insulin stimulus  
involved_in cellular response to peptide  
acts_upstream_of epithelial cell migration PubMed 
involved_in insulin receptor signaling pathway  
acts_upstream_of_or_within insulin receptor signaling pathway PubMed 
involved_in insulin receptor signaling pathway PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway PubMed 
involved_in insulin receptor signaling pathway  
acts_upstream_of_or_within mammary gland development PubMed 
involved_in negative regulation of B cell apoptotic process PubMed 
involved_in negative regulation of kinase activity PubMed 
involved_in negative regulation of long-chain fatty acid import across plasma membrane  
involved_in negative regulation of long-chain fatty acid import across plasma membrane  
involved_in positive regulation of B cell proliferation PubMed 
involved_in positive regulation of D-glucose import  
involved_in positive regulation of D-glucose import  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell migration PubMed 
involved_in positive regulation of fatty acid beta-oxidation  
involved_in positive regulation of fatty acid beta-oxidation  
involved_in positive regulation of glucose metabolic process  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of insulin secretion PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation PubMed 
involved_in response to glucose PubMed 
acts_upstream_of type B pancreatic cell proliferation PubMed 
Items 1 - 25 of 35
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
insulin receptor substrate 2
Names
4PS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081212.2NP_001074681.1  insulin receptor substrate 2

    See identical proteins and their annotated locations for NP_001074681.1

    Status: VALIDATED

    Source sequence(s)
    AC113484, AC138677
    Consensus CDS
    CCDS52477.1
    UniProtKB/Swiss-Prot
    B9EJW3, P81122
    UniProtKB/TrEMBL
    Q3U2I0
    Related
    ENSMUSP00000038514.7, ENSMUST00000040514.8
    Conserved Domains (3) summary
    cd01204
    Location:191294
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:31143
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:31143
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11034681..11058929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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