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KRT3 keratin 3 [ Homo sapiens (human) ]

Gene ID: 3850, updated on 4-Jan-2025

Summary

Official Symbol
KRT3provided by HGNC
Official Full Name
keratin 3provided by HGNC
Primary source
HGNC:HGNC:6440
See related
Ensembl:ENSG00000186442 MIM:148043; AllianceGenome:HGNC:6440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K3; CK3; MECD2
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT3 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52789685..52796117, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52754139..52770193, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53183469..53189901, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 2 binding protein pseudogene 2 Neighboring gene keratin 76 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:53184490-53185689 Neighboring gene MPRA-validated peak1735 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53206971-53207472 Neighboring gene keratin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53212003-53212504 Neighboring gene keratin 79

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Corneal dystrophy, Meesmann, 2
MedGen: C5231495 OMIM: 618767 GeneReviews: Not available
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Interactions

General gene information

Clone Names

  • FLJ95909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding PubMed 
enables structural constituent of skin epidermis  
Process Evidence Code Pubs
involved_in epithelial cell differentiation  
involved_in intermediate filament cytoskeleton organization PubMed 
involved_in intermediate filament organization  
involved_in keratinization  
Component Evidence Code Pubs
located_in cytosol  
located_in extracellular exosome PubMed 
located_in intermediate filament PubMed 
is_active_in keratin filament  
located_in keratin filament PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 3
Names
65 kDa cytokeratin
CK-3
cytokeratin 3
keratin 3, type II
type-II keratin Kb3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008350.1 RefSeqGene

    Range
    4992..11424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057088.3NP_476429.2  keratin, type II cytoskeletal 3

    See identical proteins and their annotated locations for NP_476429.2

    Status: REVIEWED

    Source sequence(s)
    AC107016, AJ628418, BM672628, CV571376
    Consensus CDS
    CCDS44895.1
    UniProtKB/Swiss-Prot
    A6NIS2, P12035, Q701L8
    Related
    ENSP00000413479.2, ENST00000417996.2
    Conserved Domains (3) summary
    pfam00038
    Location:197512
    Filament; Intermediate filament protein
    pfam16208
    Location:170194
    Keratin_2_head; Keratin type II head
    cl23720
    Location:425486
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52789685..52796117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52754139..52770193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372016.1XP_054227991.1  keratin, type II cytoskeletal 3 isoform X1

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