ASCL1 achaete-scute family bHLH transcription factor 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: ASCL1provided by CGNC
Official Full Name: achaete-scute family bHLH transcription factor 1provided by CGNC
Primary source: CGNC:49152
See related: Ensembl:ENSGALG00010011057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CASH1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (55112008..55114058, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (55413583..55415635, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing brainstem
Title: A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing hindbrain.
There is a functional relationship between specific MTG and bHLH proteins in developing chick spinal cord.
Title: Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.
This study explores the possibility of reprogramming retinal pigment epithelium progeny cells to differentiate toward retinal neurons with achaete-scute homolog 1 (ash1), a proneural gene that is expressed in progenitor cells in the developing retina.
Title: Reprogramming chick RPE progeny cells to differentiate towards retinal neurons by ash1.
induces neuronal differentiation characterized by the expression of generic neuronal genes SCG10, Hu and NF160
Title: Interaction of Mash1 and Phox2b in sympathetic neuron development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sensory organ development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: achaete-scute homolog 1

Names: achaete-scute complex homolog 1; achaete-scute complex-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204412.2 → NP_989743.2 achaete-scute homolog 1

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/TrEMBL

A0A1D5P4G9, Q90575, Q90764

Related

ENSGALP00010015074.1, ENSGALT00010026479.1

Conserved Domains (1) summary

cd19742
Location:98 → 168

bHLH_TS_ASCL1_Mash1; basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

55112008..55114058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

55413583..55415635 complement

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GenBank, FASTA, Sequence Viewer (Graphics)