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GluRIA Glutamate receptor IA [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38742, updated on 4-Jan-2025

Summary

Official Symbol
GluRIAprovided by FlyBase
Official Full Name
Glutamate receptor IAprovided by FlyBase
Primary source
FLYBASE:FBgn0004619
Locus tag
Dmel_CG8442
See related
AllianceGenome:FB:FBgn0004619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8442; DGluR-I; dglur-IA; DGluR-IA; dGluRI; DGluRI; DmelGlu-R1; Dmel\CG8442; Dro GluRIA; Glu-R1; Glu-RI; GluR1; GluR1A; GluRI; GluRIIA
Summary
Enables kainate selective glutamate receptor activity. Involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in several structures, including CNS glial cell; adult head; dorsal ectoderm anlage; ganglia; and larval midline neurons. Used to study central nervous system disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See GluRIA in Genome Data Viewer
Location:
65C1-65C1; 3-17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6624032..6635059)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6617132..6628159)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45418 Neighboring gene axundead Neighboring gene long non-coding RNA:CR45238 Neighboring gene long non-coding RNA:CR45239

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane  
is_active_in plasma membrane  
is_active_in postsynaptic density membrane  

General protein information

Preferred Names
glutamate receptor IA
Names
CG8442-PA
GluRIA-PA
glutamate receptor
glutamate receptor I
glutamate receptor kainate-selective subunit
glutamate receptor subunit
kainate receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6624032..6635059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057507.4NP_476855.1  glutamate receptor IA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6IDJ5, Q03445, Q86PC2, Q9VRX9
    Related
    FBpp0076691
    Conserved Domains (4) summary
    cd06380
    Location:41453
    PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
    cd13715
    Location:477879
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:612907
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53434
    ANF_receptor; Receptor family ligand binding region
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