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PF3D7_0615100 enoyl-acyl carrier reductase [ Plasmodium falciparum 3D7 ]

Gene ID: 3885811, updated on 11-Apr-2024

Summary

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Gene symbol
PF3D7_0615100
Gene description
enoyl-acyl carrier reductase
Locus tag
PF3D7_0615100
Gene type
protein coding
RNA name
enoyl-acyl carrier reductase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_004327.3 (623023..624321, complement)

Chromosome 6 - NC_004327.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene GPI-anchored wall transfer protein 1, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004327.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elucidating Substrate Promiscuity within the FabI Enzyme Family. Freund GS, et al. ACS Chem Biol, 2017 Sep 15. PMID 28820936
  2. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Yu M, et al. Cell Host Microbe, 2008 Dec 11. PMID 19064257, Free PMC Article
  3. Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase. Perozzo R, et al. J Biol Chem, 2002 Apr 12. PMID 11792710
  4. Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. Surolia N, et al. Nat Med, 2001 Feb. PMID 11175846
  5. Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata. Karioti A, et al. Phytomedicine, 2008 Dec. PMID 18424102

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
enoyl-acyl carrier reductase
XP_966137.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004327.3 Reference assembly

    Range
    623023..624321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_961044.1 → XP_966137.1  enoyl-acyl carrier reductase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_966137.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VUV5, A0A024WC56, A0A024XC68, C6KSZ2, W4IML9, W4ISW8, W7FRV7, W7KK09
    Conserved Domains (1) summary
    cl21454
    Location:101 → 425
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
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