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PF3D7_0624000 hexokinase [ Plasmodium falciparum 3D7 ]

Gene ID: 3885912, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0624000
Gene description
hexokinase
Locus tag
PF3D7_0624000
Gene type
protein coding
RNA name
hexokinase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_004327.3 (981066..982547)

Chromosome 6 - NC_004327.3Genomic Context describing neighboring genes Neighboring gene tyrosine kinase-like protein, putative Neighboring gene ribonuclease H2 subunit A, putative Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004327.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Davis MI, et al. Antimicrob Agents Chemother, 2016 Oct. PMID 27458230, Free PMC Article
  2. Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis. Tjhin ET, et al. FEBS Lett, 2013 Oct 1. PMID 23954294
  3. Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodium falciparum blood-stage development. Baumgarten S, et al. Nat Microbiol, 2019 Dec. PMID 31384004, Free PMC Article
  4. A network-based approach reveals novel invasion and Maurer's clefts-related proteins in Plasmodium falciparum. Das D, et al. Mol Omics, 2019 Dec 2. PMID 31631203
  5. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium-Specific Insertion.
    Title: Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium-Specific Insertion.
  2. PfHK activity was higher in 3D7-PfHK(+), they accumulated phospho-[(14)C]2-DG at the same rate as control parasites
    Title: Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables hexokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Maurer's cleft RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
hexokinase
XP_966222.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004327.3 Reference assembly

    Range
    981066..982547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_961129.1 → XP_966222.1  hexokinase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_966222.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02155
    UniProtKB/TrEMBL
    A0A024VAS3, A0A024VIP0, A0A024WBV9, A0A024WT26, A0A024XAT3, A0A0L1IF07, A0A0L7K8F6, A0A0L7M8A7, C6KT76, W4ILU2, W4IUS4, W7F4Q1, W7G9X0, W7JZC2, W7K1G9
    Conserved Domains (1) summary
    PTZ00107
    Location:23 → 487
    PTZ00107; hexokinase; Provisional
Nucleotide Protein
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