U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ABLIM1 actin binding LIM protein 1 [ Homo sapiens (human) ]

Gene ID: 3983, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ABLIM1provided by HGNC
Official Full Name
actin binding LIM protein 1provided by HGNC
Primary source
HGNC:HGNC:78
See related
Ensembl:ENSG00000099204 MIM:602330; AllianceGenome:HGNC:78
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABLIM; LIMAB1; LIMATIN; abLIM-1
Summary
This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in ovary (RPKM 50.7), heart (RPKM 50.1) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q25.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114431110..114801373, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115325183..115686686, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116190869..116528063, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116088199-116088844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116097011-116098210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116110152-116111044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116164296-116164796 Neighboring gene RNA, 7SL, cytoplasmic 384, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116219699-116220200 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:116247470-116248669 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:116249579-116250078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4083 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:116259001-116260200 Neighboring gene Sharpr-MPRA regulatory region 9264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116278667-116279186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4088 Neighboring gene Sharpr-MPRA regulatory region 11198 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116471523-116472022 Neighboring gene peptidylprolyl isomerase A pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116514326-116514855 Neighboring gene uncharacterized LOC101927692 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116581943-116582443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4092 Neighboring gene TATA-box binding protein associated factor 9b pseudogene 2 Neighboring gene FHF complex subunit HOOK interacting protein 2A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:116640543-116641171

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker. Liu D, et al. Dis Markers, 2022. PMID 36583064, Free PMC Article
  2. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. Dong X, et al. Int J Biol Sci, 2020. PMID 33061800, Free PMC Article
  3. Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. Wang KS, et al. J Mol Neurosci, 2012 Feb. PMID 21547531
  4. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. Cerván-Martín M, et al. Andrology, 2021 Jul. PMID 33784440
  5. ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1. Ohsawa N, et al. Genes Cells, 2015 Feb. PMID 25403273

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IkBalpha ubiquitination and activating NF-kB signaling.
    Title: ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
  2. Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker.
    Title: Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker.
  3. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
    Title: Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
  4. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
    Title: Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
  5. Exon 11 inclusion isoform of ABLIM1 may have a muscle-specific function, and its abnormal splicing could be related to muscle symptoms of myotonic dystrophy type 1.
    Title: ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1.
  6. SNP rs727532 in ABLIM1 (10q25) had significant association in the multivariate test & strong associations with novelty seeking, harm avoidance, reward dependence and alcohol dependence in the COGA sample.
    Title: Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide searching of rare genetic variants in WTCCC data.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC1224, FLJ14564, KIAA0059, DKFZp781D0148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
actin-binding LIM protein 1
Names
actin-binding LIM protein family member 1
actin-binding double-zinc-finger protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029872.2 RefSeqGene

    Range
    168369..395532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003407.2 → NP_001003407.1  actin-binding LIM protein 1 isoform b

    See identical proteins and their annotated locations for NP_001003407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AL133384, AL354873, AW627433, D31883
    Consensus CDS
    CCDS31288.1
    UniProtKB/TrEMBL
    F8W8M4
    Related
    ENSP00000376682.4, ENST00000392955.7
    Conserved Domains (7) summary
    smart00153
    Location:683 → 718
    VHP; Villin headpiece domain
    cd09327
    Location:39 → 90
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:95 → 150
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:166 → 217
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:225 → 280
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:290 → 682
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:520 → 580
    Rifin_STEVOR; Rifin/stevor family

  2. NM_001322882.2 → NP_001309811.1  actin-binding LIM protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (d) has a shorter, distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK122891, AL133384, AL354873
    Consensus CDS
    CCDS81509.1
    UniProtKB/TrEMBL
    F8W8M4
    Related
    ENSP00000358260.3, ENST00000369256.6
    Conserved Domains (7) summary
    smart00153
    Location:713 → 748
    VHP; Villin headpiece domain
    cd09327
    Location:39 → 90
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:95 → 150
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:166 → 217
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:225 → 280
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:318 → 712
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:550 → 610
    Rifin_STEVOR; Rifin/stevor family

  3. NM_001322883.2 → NP_001309812.1  actin-binding LIM protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL354873
    UniProtKB/TrEMBL
    F8W8M4

  4. NM_001322884.3 → NP_001309813.1  actin-binding LIM protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL137025, AL354873
    UniProtKB/TrEMBL
    F8W8M4

  5. NM_001322885.3 → NP_001309814.1  actin-binding LIM protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL137025, AL354873
    UniProtKB/TrEMBL
    F8W8M4

  6. NM_001322886.3 → NP_001309815.1  actin-binding LIM protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL137025, AL354873
    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (6) summary
    smart00153
    Location:619 → 654
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:272 → 617
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  7. NM_001322887.2 → NP_001309816.1  actin-binding LIM protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL354873
    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (7) summary
    smart00153
    Location:601 → 636
    VHP; Villin headpiece domain
    cd09327
    Location:39 → 90
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:95 → 150
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:166 → 217
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:225 → 280
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:289 → 599
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:400 → 498
    RIFIN; Rifin

  8. NM_001322888.2 → NP_001309817.1  actin-binding LIM protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL133384
    Conserved Domains (3) summary
    smart00153
    Location:420 → 455
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 418
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  9. NM_001322889.2 → NP_001309818.1  actin-binding LIM protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL133384

  10. NM_001322890.2 → NP_001309819.1  actin-binding LIM protein 1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) and variant 14 both encode isoform l.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (4) summary
    smart00153
    Location:394 → 429
    VHP; Villin headpiece domain
    pfam16182
    Location:34 → 393
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:231 → 291
    Rifin_STEVOR; Rifin/stevor family

  11. NM_001322891.2 → NP_001309820.1  actin-binding LIM protein 1 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) and variant 13 both encode isoform l.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (4) summary
    smart00153
    Location:394 → 429
    VHP; Villin headpiece domain
    pfam16182
    Location:34 → 393
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:231 → 291
    Rifin_STEVOR; Rifin/stevor family

  12. NM_001322892.2 → NP_001309821.1  actin-binding LIM protein 1 isoform n

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) and variant 16 both encode isoform n.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (4) summary
    smart00153
    Location:392 → 427
    VHP; Villin headpiece domain
    pfam16182
    Location:34 → 391
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:229 → 289
    Rifin_STEVOR; Rifin/stevor family

  13. NM_001322893.2 → NP_001309822.1  actin-binding LIM protein 1 isoform n

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) and variant 15 both encode isoform n.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (4) summary
    smart00153
    Location:392 → 427
    VHP; Villin headpiece domain
    pfam16182
    Location:34 → 391
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:229 → 289
    Rifin_STEVOR; Rifin/stevor family

  14. NM_001322894.2 → NP_001309823.1  actin-binding LIM protein 1 isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) and variant 18 both encode isoform o.
    Source sequence(s)
    AL133384
    Conserved Domains (3) summary
    smart00153
    Location:380 → 415
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 378
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  15. NM_001322895.2 → NP_001309824.1  actin-binding LIM protein 1 isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) and variant 17 both encode isoform o.
    Source sequence(s)
    AL133384
    Conserved Domains (3) summary
    smart00153
    Location:380 → 415
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 378
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  16. NM_001322896.2 → NP_001309825.1  actin-binding LIM protein 1 isoform p

    Status: REVIEWED

    Source sequence(s)
    AL133384, BC002448
    Consensus CDS
    CCDS81508.1
    UniProtKB/Swiss-Prot
    O14639
    Related
    ENSP00000358257.2, ENST00000369253.6
    Conserved Domains (2) summary
    smart00153
    Location:366 → 401
    VHP; Villin headpiece domain
    pfam16182
    Location:8 → 365
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  17. NM_001322897.2 → NP_001309826.1  actin-binding LIM protein 1 isoform q

    Status: REVIEWED

    Source sequence(s)
    AL133384
    Conserved Domains (2) summary
    smart00153
    Location:354 → 389
    VHP; Villin headpiece domain
    pfam16182
    Location:8 → 353
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  18. NM_001322898.2 → NP_001309827.1  actin-binding LIM protein 1 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) and variant 22 both encode isoform r.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B4DQA3
    Conserved Domains (4) summary
    smart00153
    Location:345 → 380
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 343
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:144 → 242
    RIFIN; Rifin

  19. NM_001322899.2 → NP_001309828.1  actin-binding LIM protein 1 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) and variant 21 both encode isoform r.
    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B4DQA3
    Conserved Domains (4) summary
    smart00153
    Location:345 → 380
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 343
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:144 → 242
    RIFIN; Rifin

  20. NM_001322900.2 → NP_001309829.1  actin-binding LIM protein 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AL133384
    Conserved Domains (2) summary
    smart00153
    Location:319 → 354
    VHP; Villin headpiece domain
    pfam16182
    Location:8 → 318
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  21. NM_001352440.1 → NP_001339369.1  actin-binding LIM protein 1 isoform u

    Status: REVIEWED

    Source sequence(s)
    AK297344, AL133384, AL354873, DC376979
    UniProtKB/TrEMBL
    A0A494C1G0, B7Z4H1, F8W8M4
    Related
    ENSP00000499023.2, ENST00000651023.2
    Conserved Domains (6) summary
    smart00153
    Location:620 → 655
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 618
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  22. NM_001352441.1 → NP_001339370.1  actin-binding LIM protein 1 isoform v

    Status: REVIEWED

    Source sequence(s)
    AL133384, AL354873, DC376979
    UniProtKB/TrEMBL
    A0A9L9PY99, F8W8M4
    Related
    ENSP00000516747.1, ENST00000707119.1
    Conserved Domains (7) summary
    smart00153
    Location:585 → 620
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 583
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:384 → 482
    RIFIN; Rifin

  23. NM_001352442.2 → NP_001339371.1  actin-binding LIM protein 1 isoform w

    Status: REVIEWED

    Source sequence(s)
    AK093471, AL133384, AL354873, DB039901
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (5) summary
    smart00153
    Location:556 → 591
    VHP; Villin headpiece domain
    cd09328
    Location:3 → 58
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:74 → 125
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:133 → 188
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:198 → 555
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  24. NM_001352443.2 → NP_001339372.1  actin-binding LIM protein 1 isoform x

    Status: REVIEWED

    Source sequence(s)
    AL133384
    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (3) summary
    smart00153
    Location:429 → 464
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:34 → 428
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  25. NM_002313.7 → NP_002304.3  actin-binding LIM protein 1 isoform a

    See identical proteins and their annotated locations for NP_002304.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF005654, AL133384, AL354873
    Consensus CDS
    CCDS7590.1
    UniProtKB/Swiss-Prot
    A6NI16, A6NJ06, A8MXA9, B3KVH2, O14639, Q15039, Q5JVV1, Q5JVV2, Q5T6N2, Q5T6N3, Q5T6N5, Q68CQ9, Q9BUP1
    UniProtKB/TrEMBL
    A0A2Z4N5U1
    Related
    ENSP00000433629.3, ENST00000533213.7
    Conserved Domains (7) summary
    smart00153
    Location:743 → 778
    VHP; Villin headpiece domain
    cd09327
    Location:99 → 150
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:155 → 210
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:226 → 277
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:285 → 340
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:350 → 742
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl14106
    Location:580 → 640
    Rifin_STEVOR; Rifin/stevor family

  26. NM_006720.4 → NP_006711.3  actin-binding LIM protein 1 isoform s

    See identical proteins and their annotated locations for NP_006711.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. It also uses a downstream start codon, compared to variant 1. The resulting isoform (s) is shorter, compared to isoform a.
    Source sequence(s)
    AI680726, AK058007, AK093471, AK122891, AL600892, AL710059, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
    Consensus CDS
    CCDS31289.1
    UniProtKB/TrEMBL
    B3KSG3
    Related
    ENSP00000376679.3, ENST00000392952.7
    Conserved Domains (4) summary
    smart00153
    Location:420 → 455
    VHP; Villin headpiece domain
    pfam16182
    Location:62 → 419
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:257 → 317
    Rifin_STEVOR; Rifin/stevor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    114431110..114801373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425242.1 → XP_047281198.1  actin-binding LIM protein 1 isoform X24

  2. XM_047425238.1 → XP_047281194.1  actin-binding LIM protein 1 isoform X19

  3. XM_047425237.1 → XP_047281193.1  actin-binding LIM protein 1 isoform X18

  4. XM_047425239.1 → XP_047281195.1  actin-binding LIM protein 1 isoform X20

  5. XM_047425232.1 → XP_047281188.1  actin-binding LIM protein 1 isoform X11

  6. XM_047425231.1 → XP_047281187.1  actin-binding LIM protein 1 isoform X10

  7. XM_047425240.1 → XP_047281196.1  actin-binding LIM protein 1 isoform X21

  8. XM_017016247.2 → XP_016871736.2  actin-binding LIM protein 1 isoform X14

  9. XM_047425234.1 → XP_047281190.1  actin-binding LIM protein 1 isoform X13

  10. XM_047425236.1 → XP_047281192.1  actin-binding LIM protein 1 isoform X15

  11. XM_024448011.2 → XP_024303779.2  actin-binding LIM protein 1 isoform X4

  12. XM_047425229.1 → XP_047281185.1  actin-binding LIM protein 1 isoform X3

  13. XM_024448010.2 → XP_024303778.2  actin-binding LIM protein 1 isoform X1

  14. XM_017016255.2 → XP_016871744.1  actin-binding LIM protein 1 isoform X22

    UniProtKB/TrEMBL
    F8W8M4

  15. XM_017016250.2 → XP_016871739.1  actin-binding LIM protein 1 isoform X17

    UniProtKB/TrEMBL
    F8W8M4

  16. XM_017016245.2 → XP_016871734.1  actin-binding LIM protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A3B3IS55

  17. XM_047425243.1 → XP_047281199.1  actin-binding LIM protein 1 isoform X25

  18. XM_047425233.1 → XP_047281189.1  actin-binding LIM protein 1 isoform X12

  19. XM_006717837.3 → XP_006717900.1  actin-binding LIM protein 1 isoform X5

    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (6) summary
    smart00153
    Location:753 → 788
    VHP; Villin headpiece domain
    cd09327
    Location:39 → 90
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:95 → 150
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:166 → 217
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:225 → 280
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:318 → 752
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  20. XM_011539802.3 → XP_011538104.2  actin-binding LIM protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A3B3IS55
    Conserved Domains (6) summary
    smart00153
    Location:743 → 778
    VHP; Villin headpiece domain
    cd09327
    Location:29 → 80
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:85 → 140
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:156 → 207
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:215 → 270
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:308 → 742
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  21. XM_017016256.2 → XP_016871745.1  actin-binding LIM protein 1 isoform X26

    UniProtKB/TrEMBL
    F8W8M4

  22. XM_024448016.2 → XP_024303784.1  actin-binding LIM protein 1 isoform X16

    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (6) summary
    smart00153
    Location:709 → 744
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:274 → 708
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  23. XM_024448018.2 → XP_024303786.1  actin-binding LIM protein 1 isoform X23

    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (6) summary
    smart00153
    Location:662 → 697
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:302 → 661
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  24. XM_024448014.2 → XP_024303782.1  actin-binding LIM protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A3B3IS55
    Conserved Domains (6) summary
    smart00153
    Location:737 → 772
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:302 → 736
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  25. XM_024448013.2 → XP_024303781.1  actin-binding LIM protein 1 isoform X7

    UniProtKB/TrEMBL
    F8W8M4
    Conserved Domains (5) summary
    smart00153
    Location:633 → 668
    VHP; Villin headpiece domain
    cd09328
    Location:3 → 58
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:74 → 125
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:133 → 188
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:198 → 632
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  26. XM_011539801.3 → XP_011538103.2  actin-binding LIM protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IS55
    Conserved Domains (5) summary
    smart00153
    Location:661 → 696
    VHP; Villin headpiece domain
    cd09328
    Location:3 → 58
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:74 → 125
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:133 → 188
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:226 → 660
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  27. XM_006717846.4 → XP_006717909.1  actin-binding LIM protein 1 isoform X27

    See identical proteins and their annotated locations for XP_006717909.1

    UniProtKB/TrEMBL
    B3KSG3
    Conserved Domains (4) summary
    smart00153
    Location:497 → 532
    VHP; Villin headpiece domain
    pfam16182
    Location:62 → 496
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl14106
    Location:334 → 394
    Rifin_STEVOR; Rifin/stevor family

  28. XM_047425245.1 → XP_047281201.1  actin-binding LIM protein 1 isoform X29

  29. XM_047425244.1 → XP_047281200.1  actin-binding LIM protein 1 isoform X28

  30. XM_047425246.1 → XP_047281202.1  actin-binding LIM protein 1 isoform X30

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    115325183..115686686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365923.1 → XP_054221898.1  actin-binding LIM protein 1 isoform X39

  2. XM_054365924.1 → XP_054221899.1  actin-binding LIM protein 1 isoform X40

  3. XM_054365913.1 → XP_054221888.1  actin-binding LIM protein 1 isoform X34

  4. XM_054365907.1 → XP_054221882.1  actin-binding LIM protein 1 isoform X31

  5. XM_054365933.1 → XP_054221908.1  actin-binding LIM protein 1 isoform X45

  6. XM_054365928.1 → XP_054221903.1  actin-binding LIM protein 1 isoform X42

  7. XM_054365927.1 → XP_054221902.1  actin-binding LIM protein 1 isoform X41

  8. XM_054365929.1 → XP_054221904.1  actin-binding LIM protein 1 isoform X43

  9. XM_054365919.1 → XP_054221894.1  actin-binding LIM protein 1 isoform X36

  10. XM_054365918.1 → XP_054221893.1  actin-binding LIM protein 1 isoform X35

  11. XM_054365908.1 → XP_054221883.1  actin-binding LIM protein 1 isoform X7

  12. XM_054365930.1 → XP_054221905.1  actin-binding LIM protein 1 isoform X44

  13. XM_054365922.1 → XP_054221897.1  actin-binding LIM protein 1 isoform X38

  14. XM_054365921.1 → XP_054221896.1  actin-binding LIM protein 1 isoform X37

  15. XM_054365911.1 → XP_054221886.1  actin-binding LIM protein 1 isoform X33

  16. XM_054365910.1 → XP_054221885.1  actin-binding LIM protein 1 isoform X32

  17. XM_054365931.1 → XP_054221906.1  actin-binding LIM protein 1 isoform X22

  18. XM_054365926.1 → XP_054221901.1  actin-binding LIM protein 1 isoform X17

  19. XM_054365917.1 → XP_054221892.1  actin-binding LIM protein 1 isoform X9

  20. XM_054365934.1 → XP_054221909.1  actin-binding LIM protein 1 isoform X25

  21. XM_054365920.1 → XP_054221895.1  actin-binding LIM protein 1 isoform X12

  22. XM_054365912.1 → XP_054221887.1  actin-binding LIM protein 1 isoform X5

  23. XM_054365914.1 → XP_054221889.1  actin-binding LIM protein 1 isoform X6

  24. XM_054365935.1 → XP_054221910.1  actin-binding LIM protein 1 isoform X26

  25. XM_054365925.1 → XP_054221900.1  actin-binding LIM protein 1 isoform X16

  26. XM_054365932.1 → XP_054221907.1  actin-binding LIM protein 1 isoform X23

  27. XM_054365916.1 → XP_054221891.1  actin-binding LIM protein 1 isoform X8

  28. XM_054365936.1 → XP_054221911.1  actin-binding LIM protein 1 isoform X2

  29. XM_054365915.1 → XP_054221890.1  actin-binding LIM protein 1 isoform X7

  30. XM_054365909.1 → XP_054221884.1  actin-binding LIM protein 1 isoform X2

  31. XM_054365937.1 → XP_054221912.1  actin-binding LIM protein 1 isoform X27

  32. XM_054365939.1 → XP_054221914.1  actin-binding LIM protein 1 isoform X47

  33. XM_054365938.1 → XP_054221913.1  actin-binding LIM protein 1 isoform X46

  34. XM_054365940.1 → XP_054221915.1  actin-binding LIM protein 1 isoform X30

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003408.1: Suppressed sequence

    Description
    NM_001003408.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14639.3 GenPept UniProtKB/Swiss-Prot:O14639

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous