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YY2 YY2 transcription factor [ Homo sapiens (human) ]

Gene ID: 404281, updated on 11-Apr-2024

Summary

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Official Symbol
YY2provided by HGNC
Official Full Name
YY2 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:31684
See related
Ensembl:ENSG00000230797 MIM:300570; AllianceGenome:HGNC:31684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF631
Summary
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]
Orthologs
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Genomic context

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Location:
Xp22.12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (21855987..21858740)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (21439288..21442041)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (21874105..21876858)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 34 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:21704726-21705925 Neighboring gene small muscle protein X-linked Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29486 Neighboring gene membrane bound transcription factor peptidase, site 2 Neighboring gene Sharpr-MPRA regulatory region 3899 Neighboring gene uncharacterized LOC124905259 Neighboring gene CYTH1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biological roles of Yin Yang 2: Its implications in physiological and pathological events. Li L, et al. J Cell Mol Med, 2020 Nov. PMID 32969187, Free PMC Article
  2. Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. Klar M, et al. Gene, 2009 Feb 1. PMID 19026728
  3. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. Luo C, et al. Genomics, 2006 Mar. PMID 16377127
  4. Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis. Li Y, et al. Adv Sci (Weinh), 2022 May. PMID 35246964, Free PMC Article
  5. The transcription factor YY2 has less momentous properties of an intrinsically disordered protein than its paralog YY1. Figiel M, et al. FEBS Lett, 2019 Jul. PMID 31131888

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis.
    Title: Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis.
  2. YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division.
    Title: YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division.
  3. Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.
    Title: Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.
  4. Biological roles of Yin Yang 2: Its implications in physiological and pathological events.
    Title: Biological roles of Yin Yang 2: Its implications in physiological and pathological events.
  5. different effects of YY1 and YY2 on gene expression patterns
    Title: The transcription factor YY2 has less momentous properties of an intrinsically disordered protein than its paralog YY1.
  6. A summary is of the published studies on the expression levels of YY1 in human cancers and their potential cross-reactivities with YY2 is also provided. Well-documented monospecific antibodies to both YY1 and YY2 have to be developed and used when examining the expression levels of YY1 and YY2 in human cancers to elucidate the accurate relationship between them and clinical significance of each.
    Title: The Forgotten YY2 in Reported YY1 Expression Levels in Human Cancers.
  7. In human colorectal cancer metastases to the liver, the levels of AES protein are correlated with those of YY2
    Title: Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
  8. article summarizes all critical aspects that are (or will be) relevant for a better understanding of YY1- and/or YY2-mediated cellular control mechanisms
    Title: Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.
  9. Results show that human YY2 is not redundant to YY1, and YY2 is a significant regulator of genes previously identified as uniquely responding to YY1.
    Title: Genome-wide analysis of YY2 versus YY1 target genes.
  10. yy2 expression is mediated by its own methylation-sensitive promoter.
    Title: Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor YY2
Names
transcription factor yin yang 2
yin and yang 2
zinc finger protein 631

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021268.1 RefSeqGene

    Range
    5001..7754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206923.4 → NP_996806.2  transcription factor YY2

    See identical proteins and their annotated locations for NP_996806.2

    Status: REVIEWED

    Source sequence(s)
    AK091850, BC137215, DB029513, DB459498, U73479
    Consensus CDS
    CCDS14202.1
    UniProtKB/Swiss-Prot
    B2RP10, O15391, Q6Q1S4
    Related
    ENSP00000389381.2, ENST00000429584.3
    Conserved Domains (4) summary
    COG5048
    Location:309 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:298 → 323
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:255 → 334
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    21855987..21858740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    21439288..21442041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15391.1 GenPept UniProtKB/Swiss-Prot:O15391

Gene LinkOut

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