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RpLP0 Ribosomal protein LP0 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40451, updated on 10-May-2024

Summary

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Official Symbol
RpLP0provided by FlyBase
Official Full Name
Ribosomal protein LP0provided by FlyBase
Primary source
FLYBASE:FBgn0000100
Locus tag
Dmel_CG7490
See related
AllianceGenome:FB:FBgn0000100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ap3; AP3; Ape; CG7490; Dmel\CG7490; l(3)0154; l(3)01544; L10; LP0; p0; P0; P35; PO; RLA0; RPL P0; Rplp0; RpP0; RpPO
Summary
Enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity. A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including RPLP0 (ribosomal protein lateral stalk subunit P0). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See RpLP0 in Genome Data Viewer
Location:
79B2-79B2; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22075867..22077487)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22068967..22070587)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 79 Neighboring gene male-specific opa containing gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease. Kelley MR, et al. Mol Cell Biol, 1989 Mar. PMID 2471063, Free PMC Article
  2. Drosophila apurinic/apyrimidinic DNA endonucleases. Characterization of mechanism of action and demonstration of a novel type of enzyme activity. Spiering AL, et al. J Biol Chem, 1986 Mar 5. PMID 2419327
  3. Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein P0. Grabowski DT, et al. Nucleic Acids Res, 1991 Aug 11. PMID 1870984, Free PMC Article
  4. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity. Yacoub A, et al. Nucleic Acids Res, 1996 Nov 1. PMID 8932386, Free PMC Article
  5. Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes. Satterfield TF, et al. Hum Mol Genet, 2006 Aug 15. PMID 16835262

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embryo cytoplasms
    Title: Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in nucleic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein LP0
Names
60S ribosomal protein P0
ACIDIC RIBOSOMAL PROTEIN LP0
CG7490-PA
CG7490-PB
RpLP0-PA
RpLP0-PB
apurinic endonuclease 3
ribosomal protein P0

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22075867..22077487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275273.1 → NP_001262202.1  ribosomal protein LP0, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19889, Q5BHX7, Q9VNV9
    UniProtKB/TrEMBL
    M9PG76
    Conserved Domains (3) summary
    cd05795
    Location:8 → 182
    Ribosomal_P0_L10e; Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk ...
    PTZ00135
    Location:1 → 275
    PTZ00135; 60S acidic ribosomal protein P0; Provisional
    pfam00428
    Location:232 → 285
    Ribosomal_60s; 60s Acidic ribosomal protein

  2. NM_079487.4 → NP_524211.1  ribosomal protein LP0, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524211.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19889, Q5BHX7, Q9VNV9
    UniProtKB/TrEMBL
    M9PG76
    Related
    FBpp0078134
    Conserved Domains (3) summary
    cd05795
    Location:8 → 182
    Ribosomal_P0_L10e; Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk ...
    PTZ00135
    Location:1 → 275
    PTZ00135; 60S acidic ribosomal protein P0; Provisional
    pfam00428
    Location:232 → 285
    Ribosomal_60s; 60s Acidic ribosomal protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG76 M9PG76
P19889.1 P19889

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