dusp1 dual specificity phosphatase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dusp1provided by ZNC
Official Full Name: dual specificity phosphatase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2018
See related: Ensembl:ENSDARG00000100515 AllianceGenome:ZFIN:ZDB-GENE-040426-2018
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb269; sb:cb269; zgc:55920; id:ibd2586; wu:fd19g02; wu:fe50g09
Summary: Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine/threonine phosphatase activity. Predicted to be involved in endoderm formation and negative regulation of p38MAPK cascade. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including forebrain neural keel; margin; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (15760253..15763624, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (15454690..15458061, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity.
Title: Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity.

Submit: New GeneRIF Correction

General gene information

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Markers

fe50g09.x1 (e-PCR)
- UniSTS:204411

AI722551 (e-PCR)
- UniSTS:206004

fd19g02.x1 (e-PCR)
- UniSTS:204254

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in endoderm formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase 1

Names: mkp-1

NP_998232.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213067.1 → NP_998232.1 dual specificity protein phosphatase 1

See identical proteins and their annotated locations for NP_998232.1

Status: PROVISIONAL

Source sequence(s)

BC045494

UniProtKB/TrEMBL

Q7ZVL8

Related

ENSDARP00000137487.1, ENSDART00000160712.2

Conserved Domains (3) summary

COG2453
Location:225 → 326

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

cd00127
Location:175 → 311

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:8 → 137

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...