prim2 DNA primase subunit 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prim2provided by ZNC
Official Full Name: DNA primase subunit 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-471
See related: Ensembl:ENSDARG00000052721 AllianceGenome:ZFIN:ZDB-GENE-050522-471
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PRIM2A; wu:fa11h04; zgc:110727
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity; DNA binding activity; and metal ion binding activity. Predicted to act upstream of or within DNA replication, synthesis of RNA primer. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (23488256..23612398, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (23357847..23481949, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication, synthesis of primer	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication, synthesis of primer	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of alpha DNA polymerase:primase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of primosome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA primase large subunit

Names: DKEYP-80F12.1; primase, DNA, polypeptide 2; primase, polypeptide 2A, 58kDa

NP_999947.1

EC 2.7.7.-

XP_005156868.1

EC 2.7.7.-

XP_017214219.1

EC 2.7.7.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214782.2 → NP_999947.1 DNA primase large subunit

See identical proteins and their annotated locations for NP_999947.1

Status: PROVISIONAL

Source sequence(s)

BC095387

UniProtKB/TrEMBL

Q6TGV8

Related

ENSDARP00000115722.1, ENSDART00000136406.3

Conserved Domains (2) summary

cd07322
Location:25 → 456

PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

COG2219
Location:36 → 418

PRI2; Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

23488256..23612398 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156811.4 → XP_005156868.1 DNA primase large subunit isoform X1

See identical proteins and their annotated locations for XP_005156868.1

UniProtKB/TrEMBL

A0A8M2B2Y8, B8JIP2

Related

ENSDARP00000012598.8, ENSDART00000005004.10

Conserved Domains (2) summary

cd07322
Location:25 → 456

PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

COG2219
Location:36 → 418

PRI2; Eukaryotic-type DNA primase, large subunit [Replication, recombination and repair]
XM_017358730.2 → XP_017214219.1 DNA primase large subunit isoform X2

UniProtKB/TrEMBL

A0A8M6Z9J9