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RT1-CE16 RT1 class I, locus CE16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 414819, updated on 13-Apr-2024

Summary

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Symbol
RT1-CE16provided by RGD
Full Name
RT1 class I, locus CE16provided by RGD
Primary source
RGD:1359403
See related
Ensembl:ENSRNOG00000065254 AllianceGenome:RGD:1359403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RT1-Uc; RT1.Cg; RT1-Uav1; RT1-Ulv1
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3261656..3265548, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3257109..3260747, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene transcription factor 19 Neighboring gene POU class 5 homeobox 1 Neighboring gene uncharacterized LOC108353253 Neighboring gene Cdk2ap1-ps8 pseudogene Neighboring gene RT1 class I, locus CE15 Neighboring gene uncharacterized LOC120098828 Neighboring gene LOC224733l-9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequences of three distinct cDNA clones coding for the rat class I heavy chain RT1n antigen. Wang M, et al. Immunogenetics, 1996. PMID 8881041
  2. Characterization of two class I major histocompatibility rat cDNA clones, one of which contains a premature termination codon. Kastern W. Gene, 1985. PMID 3839199
  3. Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats. Dai KZ, et al. J Immunol, 2018 Apr 15. PMID 29531166, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP complex binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide antigen assembly with MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of memory T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
located_in lumenal side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RT1 class I, locus CE16
Names
MHC class Ib alpha chain
MHC class Ib molecule
MHC class Ib, RT1-Uav1
MHC class Ib, RT1-Uc
MHC class Ib, RT1-Ulv1
RT1 class I histocompatibility antigen, AA alpha chain-like
RT1 class I, CE16 precursor, RT1-Un
class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like
mature MHC class I alpha heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008839.2 → NP_001008839.1  RT1 class I, locus CE16 precursor

    See identical proteins and their annotated locations for NP_001008839.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A2P1NRY6, P79589, Q6MG28
    Related
    ENSRNOP00000057699.5, ENSRNOT00000060980.4
    Conserved Domains (2) summary
    cd07698
    Location:207 → 299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:25 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3261656..3265548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279421.1 → XP_063135491.1  RT1 class I, locus CE16 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YPS9

  2. XM_063279422.1 → XP_063135492.1  RT1 class I, locus CE16 isoform X2

  3. XM_063279423.1 → XP_063135493.1  RT1 class I, locus CE16 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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