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MCM6 minichromosome maintenance complex component 6 [ Homo sapiens (human) ]

Gene ID: 4175, updated on 4-Jan-2025

Summary

Official Symbol
MCM6provided by HGNC
Official Full Name
minichromosome maintenance complex component 6provided by HGNC
Primary source
HGNC:HGNC:6949
See related
Ensembl:ENSG00000076003 MIM:601806; AllianceGenome:HGNC:6949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mis5; P105MCM; MCG40308
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Expression
Broad expression in lymph node (RPKM 19.9), bone marrow (RPKM 13.7) and 24 other tissues See more
Orthologs
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Genomic context

See MCM6 in Genome Data Viewer
Location:
2q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (135839626..135876443, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (136284082..136320862, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (136597196..136634013, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16577 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:136499891-136500666 Neighboring gene UBX domain protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:136554979-136555500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:136555501-136556024 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:136574960-136576159 Neighboring gene lactase Neighboring gene LCT antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:136633103-136633638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:136656467-136656966 Neighboring gene MANEAL pseudogene 1 Neighboring gene uncharacterized LOC124906078 Neighboring gene aspartyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Nonpersistence of intestinal lactase
MedGen: C0268181 OMIM: 223100 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 6 (MCM6) in the nucleoli of Jurkat T-cells PubMed
tat Interaction of HIV-1 Tat with MCM6 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr HIV-1 Vpr downregulates MCM6 in HeLa cells within 12 hours of exposure PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding PubMed 
enables ATP hydrolysis activity  
enables ATP-dependent H2AZ histone chaperone activity  
enables ATP-dependent H3-H4 histone complex chaperone activity  
enables DNA clamp loader activity  
contributes_to DNA helicase activity PubMed 
enables chromatin extrusion motor activity  
enables cohesin loader activity  
enables double-stranded DNA helicase activity  
enables forked DNA-dependent helicase activity  
enables four-way junction helicase activity  
enables identical protein binding PubMed 
enables protein binding PubMed 
contributes_to single-stranded 3'-5' DNA helicase activity  
contributes_to single-stranded DNA binding PubMed 
contributes_to single-stranded DNA binding  
Component Evidence Code Pubs
part_of CMG complex PubMed 
part_of CMG complex  
part_of MCM complex  
part_of MCM complex PubMed 
part_of MCM complex PubMed 
located_in chromosome, telomeric region PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM6
Names
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
minichromosome maintenance deficient (mis5, S. pombe) 6
NP_005906.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008958.1 RefSeqGene

    Range
    4999..41816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005915.6NP_005906.2  DNA replication licensing factor MCM6

    See identical proteins and their annotated locations for NP_005906.2

    Status: REVIEWED

    Source sequence(s)
    AA577398, BC020268, BC032374, CN389677, DA521248
    Consensus CDS
    CCDS2179.1
    UniProtKB/Swiss-Prot
    B2R6H2, Q13504, Q14566, Q99859
    UniProtKB/TrEMBL
    Q4ZG57
    Related
    ENSP00000264156.2, ENST00000264156.3
    Conserved Domains (3) summary
    smart00350
    Location:119657
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:27114
    MCM_N; MCM N-terminal domain
    pfam18263
    Location:713817
    MCM6_C; MCM6 C-terminal winged-helix domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    135839626..135876443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    136284082..136320862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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