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MEIS1 Meis homeobox 1 [ Homo sapiens (human) ]

Gene ID: 4211, updated on 4-Jan-2025

Summary

Official Symbol
MEIS1provided by HGNC
Official Full Name
Meis homeobox 1provided by HGNC
Primary source
HGNC:HGNC:7000
See related
Ensembl:ENSG00000143995 MIM:601739; AllianceGenome:HGNC:7000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 12.6) and 21 other tissues See more
Orthologs
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Genomic context

See MEIS1 in Genome Data Viewer
Location:
2p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (66435125..66573869)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (66444205..66582943)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66662257..66801001)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene E4 enhancer upstream of MEIS1 Neighboring gene Sharpr-MPRA regulatory region 4056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:66617956-66618568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:66618569-66619179 Neighboring gene long intergenic non-protein coding RNA 1873 Neighboring gene MEIS1 5' regulatory region Neighboring gene MEIS1 antisense RNA 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:66666573-66667772 Neighboring gene E2 enhancer in MEIS1 Neighboring gene HHc2:066588 enhancer in MEIS1 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene E5 enhancer in MEIS1 Neighboring gene HHc2:066628 enhancer in MEIS1 Neighboring gene E7 enhancer in MEIS1 Neighboring gene HCNR606 enhancer in MEIS1 Neighboring gene uncharacterized LOC124900511 Neighboring gene HHc2:066650 enhancer in MEIS1 Neighboring gene HCNR617 enhancer in MEIS1 Neighboring gene HHc2:066659 enhancer in MEIS1 Neighboring gene HHc2:067135 enhancer in MEIS1 Neighboring gene HHc2:067347 enhancer downstream of MEIS1 Neighboring gene long intergenic non-protein coding RNA 1798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:66874822-66875386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:66875387-66875950 Neighboring gene long intergenic non-protein coding RNA 1797

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide association studies of the PR interval in African Americans.
EBI GWAS Catalog
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
EBI GWAS Catalog
Genome-wide association study of PR interval.
EBI GWAS Catalog
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC43380

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in angiogenesis  
involved_in animal organ morphogenesis  
involved_in brain development  
involved_in cell growth involved in cardiac muscle cell development  
involved_in definitive hemopoiesis  
involved_in embryonic pattern specification  
involved_in eye development  
involved_in hemopoiesis  
involved_in lens morphogenesis in camera-type eye  
involved_in locomotory behavior  
involved_in megakaryocyte development  
involved_in negative regulation of myeloid cell differentiation  
involved_in negative regulation of neuron differentiation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of transcription by RNA polymerase II  
Component Evidence Code Pubs
located_in chromatin  
part_of transcription regulator complex  

General protein information

Preferred Names
homeobox protein Meis1
Names
Meis1, myeloid ecotropic viral integration site 1 homolog
WUGSC:H_NH0444B04.1
leukemogenic homolog protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011467.1 RefSeqGene

    Range
    4726..143470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002398.3NP_002389.1  homeobox protein Meis1

    See identical proteins and their annotated locations for NP_002389.1

    Status: REVIEWED

    Source sequence(s)
    AC007392, AC092669, AI203963, AL832770, BC043503, CB854199, U85707
    Consensus CDS
    CCDS46309.1
    UniProtKB/Swiss-Prot
    A8MV50, O00470
    UniProtKB/TrEMBL
    B2RC57
    Related
    ENSP00000272369.8, ENST00000272369.14
    Conserved Domains (2) summary
    pfam05920
    Location:290329
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:108192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    66435125..66573869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    66444205..66582943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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