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Delta delta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42313, updated on 4-Jan-2025

Summary

Official Symbol
Deltaprovided by FlyBase
Official Full Name
deltaprovided by FlyBase
Primary source
FLYBASE:FBgn0000463
Locus tag
Dmel_CG3619
See related
AllianceGenome:FB:FBgn0000463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0495/20; 0926/11; 1053/14; 1119/09; 1304/03; 1423/11; 1440/11; 1485/04; anon-WO0118547.269; C1; CG3619; CT12133; D1; delta; delta D1; Deltal; Dl; DL; dmDelta; Dmel\CG3619; E(ls)2; EC3-5; l(3)05151; l(3)92Ab; l(3)j8C3
Summary
Enables Notch binding activity; glycosphingolipid binding activity; and receptor ligand activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; neurogenesis; and oogenesis. Located in several cellular components, including apical cortex; cell surface; and cytoplasmic vesicle. Colocalizes with cytoplasmic vesicle. Is expressed in several structures, including epithelium; gut section; imaginal disc; photoreceptor neurons; and somatic precursor cell. Used to study cancer and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to several human genes including DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Delta in Genome Data Viewer
Location:
92A1-92A2; 3-66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19302731..19326217, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15128453..15151939, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43451 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44175 Neighboring gene hairpin RNA:CR46343 Neighboring gene long non-coding RNA:CR43258

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding  
enables Notch binding PubMed 
enables Notch binding PubMed 
enables calcium ion binding  
enables glycosphingolipid binding PubMed 
enables protein binding PubMed 
enables receptor ligand activity PubMed 
Items 1 - 25 of 41
Process Evidence Code Pubs
involved_in Notch signaling pathway  
involved_in Notch signaling pathway PubMed 
involved_in Notch signaling pathway  
involved_in Notch signaling pathway PubMed 
involved_in Notch signaling pathway PubMed 
involved_in R3/R4 cell differentiation PubMed 
involved_in R7 cell differentiation PubMed 
involved_in actin filament organization PubMed 
involved_in antennal morphogenesis PubMed 
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces PubMed 
involved_in asymmetric cell division PubMed 
involved_in border follicle cell migration PubMed 
involved_in cell communication  
involved_in cell fate specification PubMed 
involved_in chaeta morphogenesis PubMed 
involved_in compound eye photoreceptor development PubMed 
involved_in compound eye retinal cell programmed cell death PubMed 
involved_in follicle cell of egg chamber development PubMed 
involved_in follicle cell of egg chamber stalk formation PubMed 
involved_in germ-line stem cell population maintenance PubMed 
involved_in glial cell migration PubMed 
involved_in imaginal disc-derived leg morphogenesis PubMed 
involved_in imaginal disc-derived leg segmentation PubMed 
involved_in imaginal disc-derived wing margin morphogenesis PubMed 
involved_in imaginal disc-derived wing morphogenesis PubMed 
involved_in lateral inhibition PubMed 
involved_in mesoderm development PubMed 
involved_in negative regulation of Notch signaling pathway  
involved_in neuroblast fate determination PubMed 
involved_in neuron fate specification PubMed 
involved_in oocyte localization involved in germarium-derived egg chamber formation PubMed 
involved_in oogenesis PubMed 
involved_in peripheral nervous system development PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of mitotic cell cycle PubMed 
involved_in regulation of establishment of planar polarity PubMed 
involved_in second mitotic wave involved in compound eye morphogenesis PubMed 
involved_in sensory organ development PubMed 
involved_in stem cell differentiation PubMed 
involved_in wing disc anterior/posterior pattern formation PubMed 
involved_in wing disc dorsal/ventral pattern formation PubMed 
Items 1 - 25 of 41
Component Evidence Code Pubs
located_in apical cortex PubMed 
located_in cell surface PubMed 
colocalizes_with cytoplasmic vesicle PubMed 
located_in cytoplasmic vesicle PubMed 
located_in early endosome PubMed 
located_in endocytic vesicle PubMed 
located_in endosome PubMed 
located_in membrane PubMed 
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
delta
Names
CG3619-PA
CG3619-PB
CG3619-PC
Delta-PA
Delta-PB
Delta-PC
complementation group 1
overflow

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19302731..19326217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057916.4 → NP_477264.1  delta, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477264.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
    UniProtKB/TrEMBL
    A4V346
    Related
    FBpp0083153
    Conserved Domains (3) summary
    cd00054
    Location:529 → 564
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:164 → 226
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 96
    MNNL; N terminus of Notch ligand
  2. NM_001260264.2 → NP_001247193.1  delta, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247193.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
    UniProtKB/TrEMBL
    A4V346
    Conserved Domains (3) summary
    cd00054
    Location:529 → 564
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:164 → 226
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 96
    MNNL; N terminus of Notch ligand
  3. NM_169853.3 → NP_732412.1  delta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732412.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
    UniProtKB/TrEMBL
    A4V346
    Related
    FBpp0083154
    Conserved Domains (3) summary
    cd00054
    Location:529 → 564
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:164 → 226
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 96
    MNNL; N terminus of Notch ligand
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