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MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Gallus gallus (chicken) ]

Gene ID: 423508, updated on 5-Mar-2024

Summary

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Symbol
MTHFD1provided by CGNC
Full Name
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by CGNC
Primary source
CGNC:8944
See related
Ensembl:ENSGALG00010017583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (52431500..52473180, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (52410219..52451836, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene uncharacterized LOC124418019 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124418020 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene estrogen receptor 2 Neighboring gene uncharacterized LOC121110835 Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene transfer RNA leucine (anticodon CAG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic
Names
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NP_001034392.2
NP_001384156.1
NP_001384157.1
NP_001384158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039303.2 → NP_001034392.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    Q5ZI76
    Related
    ENSGALP00010025011.1, ENSGALT00010042521.1
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  2. NM_001397227.1 → NP_001384156.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    Q5ZI76
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 937
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  3. NM_001397228.1 → NP_001384157.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    Q5ZI76
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

  4. NM_001397229.1 → NP_001384158.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    Q5ZI76
    Conserved Domains (2) summary
    PLN02759
    Location:310 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    52431500..52473180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    52410219..52451836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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