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wfs1 wolfram syndrome 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42679, updated on 4-Jan-2025

Summary

Official Symbol
wfs1provided by FlyBase
Official Full Name
wolfram syndrome 1provided by FlyBase
Primary source
FLYBASE:FBgn0039003
Locus tag
Dmel_CG4917
See related
AllianceGenome:FB:FBgn0039003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4917; Dmel\CG4917; WFS1
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in adult locomotory behavior and negative regulation of gene expression. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in several diseases, including Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See wfs1 in Genome Data Viewer
Location:
94C1-94C1; 3-76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22687542..22690380, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18513264..18516102, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutamate-cysteine ligase modifier subunit Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 133kD Neighboring gene cardinal

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane  

General protein information

Preferred Names
wolfram syndrome 1
Names
CG4917-PA
CG4917-PC
wfs1-PA
wfs1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22687542..22690380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202338.2 → NP_001189267.1  wolfram syndrome 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDG5
    Conserved Domains (1) summary
    COG0790
    Location:34 → 153
    TPR; TPR repeat [Signal transduction mechanisms]
  2. NM_142822.3 → NP_651079.2  wolfram syndrome 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651079.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4JDG5, Q8IMZ9, Q8MS19
    Related
    FBpp0083727
    Conserved Domains (1) summary
    COG0790
    Location:34 → 154
    TPR; TPR repeat [Signal transduction mechanisms]
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