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Hmgcr HMG Coenzyme A reductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42803, updated on 4-Jan-2025

Summary

Official Symbol
Hmgcrprovided by FlyBase
Official Full Name
HMG Coenzyme A reductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0263782
Locus tag
Dmel_CG10367
See related
AllianceGenome:FB:FBgn0263782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; Dmel\CG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; HMGR; hmgrc; l(3)01152; l(3)04684
Summary
Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in several processes, including ecdysis, chitin-based cuticle; embryonic heart tube development; and germ cell attraction. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including adult brain cell body rind; adult fat body; anterior-posterior subdivision of organism; gland; and gut section. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Hmgcr in Genome Data Viewer
Location:
95B1-95B1; 3-80 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23733324..23750992)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19559046..19576714)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease MRP RNA Neighboring gene Regulatory particle non-ATPase 9 Neighboring gene antisense RNA:CR46091 Neighboring gene Ran binding protein 3 Neighboring gene Regulatory particle triple-A ATPase 5 Neighboring gene HMG-coA reductase degradation 3 Neighboring gene Protein tyrosine phosphatase, mitochondrial 1

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in peroxisomal membrane  
located_in peroxisomal membrane PubMed 

General protein information

Preferred Names
HMG coenzyme A reductase
Names
3-Hydroxy-3-Methylglutaryl CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase
CG10367-PA
HMG-CoA reductase
HMG-CoA reductase class I
HMGCo-A reductase
HMGCoA reductase
Hmg-CoA-reductase
Hmgcr-PA
columbus
lethal (3) 04684
NP_732900.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23733324..23750992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170089.2 → NP_732900.1  HMG coenzyme A reductase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3A8, P14773, Q9VCI8
    UniProtKB/TrEMBL
    A9UN11, E1JIU8
    Related
    FBpp0083842
    Conserved Domains (3) summary
    cd00643
    Location:489 → 897
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1 → 920
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:133 → 263
    MMPL; MMPL family
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